Evaluation of utero-placental and fetal hemodynamic parameters throughout gestation in pregnant mice using high-frequency ultrasound.
Evaluation of utero-placental and fetal hemodynamic parameters throughout gestation in pregnant mice using high-frequency ultrasound.
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DOI：
10.1016/j.ultrasmedbio.2013.09.026
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发表时间：
2014-02
影响因子：
2.9
通讯作者：
Romero, Roberto
中科院分区：
文献类型：
--
作者：
Hernandez-Andrade, Edgar;Ahn, Hyunyoung;Szalai, Gabor;Korzeniewski, Steven J.;Wang, Bing;King, Mary;Chaiworapongsa, Tinnakorn;Than, Nandor Gabor;Romero, Roberto
描述了使用具有 55 MHz 线性探头的高频超声在怀孕小鼠中母体和胎儿多普勒参数在整个妊娠过程中的变化，类似于在人类胎儿中获得的变化。子宫动脉 (UtA)、胎儿脐带 (UA) 和胎儿静脉导管 (DV) 显示：收缩期峰值速度增加（UtA，p=0.04；UA，p=0.0004；DV，p=0.02），舒张末期速度降低（UtA，p<0.001；UA，p<.0001；DV， p=0.01），并且在妊娠末期阻力指数降低（UtA，p=0.0004；UA，p=0.0001；DV，p=0.04）。大脑中动脉 (MCA) 和颈动脉 (CAR) 显示舒张末期速度降低（MCA，p=0.02；CAR，p<0.0001）和阻力指数（两条血管，p<0.0001）。脐静脉显示搏动模式减少（p<0.05）。速度的增加和阻力指数的降低表明在妊娠末期胎儿小鼠的血流量逐渐增加。使用高频超声可以可靠地评估 CD-1 小鼠的胎儿和子宫胎盘血管参数。
Changes throughout gestation of maternal and fetal Doppler parameters in pregnant mice, similar to those obtained in human fetuses, using a high frequency ultrasound with a 55 MHz linear probe are described. The uterine arteries (UtA), fetal umbilical (UA) and fetal ductus venosus (DV) showed: increased peak systolic velocity (UtA, p=0.04; UA, p=0.0004; DV, p=0.02), reduced end diastolic velocity (UtA, p<0.001; UA, p<.0001; DV, p=0.01), and reduced resistance index (UtA, p=0.0004; UA, p=0.0001; DV, p=0.04) toward the end of pregnancy. The middle cerebral (MCA) and carotid arteries (CAR) showed reduced end diastolic velocity (MCA, p=0.02; CAR, p<0.0001), and resistance index (both vessels, p<0.0001). The umbilical vein showed a reduction in the pulsatile pattern (p<0.05). Increased velocities and reduced resistance index suggest a progressive increment in blood flow to the fetal mouse towards the end of pregnancy. Evaluation of fetal and utero-placental vascular parameters in CD-1 mice can be reliably performed using high frequency ultrasound.
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