UV resonance Raman investigations of peptide and protein structure and dynamics.
UV resonance Raman investigations of peptide and protein structure and dynamics.
复制标题
DOI：
10.1021/cr200198a
复制
发表时间：
2012-05-09
期刊：
影响因子：
62.1
通讯作者：
Lednev, Igor K.
中科院分区：
文献类型：
--
作者：
Oladepo, Sulayman A.;Xiong, Kan;Hong, Zhenmin;Asher, Sanford A.;Handen, Joseph;Lednev, Igor K.
1.1.蛋白质折叠问题对蛋白质折叠机制的理解，即核糖体合成的生物聚合物折叠成其天然蛋白质，可以说是生物学中最重要的未解决的问题之一。许多或大多数蛋白质的一级序列编码天然结构和天然结构的折叠机制途径。在过去的50年里，许多研究小组已经研究了蛋白质折叠的机制，其主要目标是开发从蛋白质一级序列预测天然构象的方法。对编码蛋白质折叠“规则”的理解将大大加快对蛋白质结构和功能的洞察;这一知识将导致治疗人类疾病的药物的第一原理设计，其中许多是由蛋白质突变和/或蛋白质错误折叠引起的。大量的理论和实验文献存在于蛋白质折叠。已经提出了许多在折叠事件的顺序上不同的机制。例如，框架模型11和扩散碰撞模型12提出折叠的初始步骤涉及天然二级结构单元的形成，而疏水性塌陷模型13，14和成核-缩合模型14表明疏水或成核结构域首先折叠，并且这些结构驱动随后的二级结构形成。最近的能量景观模型4，15 - 24提出了漏斗形折叠能量景观的发生，其中天然状态是通过战略倾斜的能量景观，漏斗无数的部分折叠构象向天然折叠状态。四、二十五、二十六
1.1. Protein Folding Problem An understanding of the mechanism (s) of protein folding, whereby the ribosome synthesized biopolymer folds into its native protein, is arguably one of the most important unsolved problems in biology. 1À7 The primary sequence of many or most proteins encodes both the native structure and the folding mechanism pathway to the native structure. 8À10 Over the last 50 years numerous groups have examined the mechanisms of protein folding, with a major objective being to develop methods to predict the native conformation from the primary protein sequence. An understanding of the encoded protein folding “rules” would dramatically speed insight into protein structure and function; this knowledge would result in the first principles design of drugs to treat human diseases, many of which result from protein mutations and/or from protein misfolding. A vast theoretical and experimental literature exists on protein folding. A number of mechanisms have been proposed that differ in the order of folding events. For example, the framework model11 and the diffusion-collision model12 propose that the initial step in folding involves formation of native-like secondary structural units, whereas the hydrophobic collapse model13, 14 and the nucleation-condensation model14 suggest that hydrophobic or nucleating domains fold first, and that these structures drive the subsequent formation of secondary structure. Recent energy landscape models4, 15À24 propose the occurrence of funnel-shaped folding energy landscapes, where the native state is accessed via a strategically sloped energy landscape that funnels myriads of partially folded conformations toward the native folded state. 4, 25, 26
登录
查看更多内容
影响因子：
13.8
作者：
Baldwin, RL;Rose, GD
通讯作者：
Rose, GD
影响因子：
7.4
作者：
ASHER, SA
通讯作者：
ASHER, SA
影响因子：
3.3
作者：
Balakrishnan, Gurusamy;Hu, Ying;Spiro, Thomas G.
通讯作者：
Spiro, Thomas G.
影响因子：
13.8
作者：
Baldwin, RL;Rose, GD
通讯作者：
Rose, GD
DOI：
10.1107/s0567740882004075
发表时间：
1982-01-01
期刊：
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE
影响因子：
--
作者：
ARTYMIUK, PJ;BLAKE, CCF;WILSON, KS
通讯作者：
WILSON, KS