Clock at the Core of Cancer Development.
Clock at the Core of Cancer Development.
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DOI：
10.3390/biology10020150
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发表时间：
2021-02-14
期刊：
影响因子：
4.2
通讯作者：
Kondratov RV
中科院分区：
文献类型：
--
作者：
Patel SA;Kondratov RV
地球自转产生一天24小时的昼夜循环。许多生物功能，如睡眠-觉醒周期、进食/禁食周期、血液激素水平和体温节律在24小时内发生。这些每日的波动由一个被称为生物钟的内部系统控制(拉丁语中的“前后”和“日”)。这种时钟协调各种生理和行为活动的周期性变化，有助于适应周期性环境，有利于生物的生存和繁殖。几乎所有的生物体，从单细胞到哺乳动物，包括人类，都有一个自我维持的生物钟。体内生物钟功能的紊乱可能会改变生物功能的平衡，损害生物体的健康。在人类中，生物钟紊乱与糖尿病、心血管疾病和癌症等疾病有关。因此，研究生物钟和生理学之间的相互作用对于预防和管理癌症等致命疾病非常重要。为了使各种生物过程与昼夜周期同步，大多数生物体都研制出了生物钟。这个进化上保守的系统在行为、生理和新陈代谢的时间调节中很重要。与昼夜节律紊乱相关的多种病理变化支持了时钟在哺乳动物中的重要性。新出现的联系揭示了癌症中生物钟和信号网络之间的相互作用。了解生物钟和肿瘤发生之间的相互作用对于其预防、管理和开发有效的治疗方案是必不可少的。在这篇综述中，我们综述了生物钟在调节一个重要的代谢途径--胰岛素/IGF1/PI3K/mTOR信号通路中的作用，以及这一代谢途径的失调如何导致癌细胞的增殖和生长失控。通过最近发现的药物或通过环境线索来定位生物钟和节律是癌症计时治疗的一个新方向。将昼夜节律方法与传统方法相结合，如放射治疗、化疗或最近开发的免疫疗法，可能会改善肿瘤反应，同时将通常与癌症治疗相关的不良反应降至最低。
The earth’s rotation produces a daily 24 h cycle of day and night. Many biological functions, such as sleep–wake cycle, feeding/fasting cycle, blood hormone levels and body temperature rhythms occur over a 24 h period. These daily fluctuations are controlled by an internal system known as the circadian clock (Latin circa—“around”—and diem—“day”). This clock coordinates the periodic changes in diverse physiological and behavioral activities and helps adapt to the periodic environment for the benefit of survival and reproduction of organisms. Nearly all organisms, from single-cell to mammals, including humans, possess a self-sustained circadian clock. Disturbances in the functioning of this internal circadian clock can alter the balance in biological functions and compromise organism fitness. In humans, clock disruption is associated with diseases such as diabetes, cardiovascular diseases and cancer. Thus, studying the interplay between the circadian clock and physiology is important in the prevention and management of fatal diseases such as cancer. To synchronize various biological processes with the day and night cycle, most organisms have developed circadian clocks. This evolutionarily conserved system is important in the temporal regulation of behavior, physiology and metabolism. Multiple pathological changes associated with circadian disruption support the importance of the clocks in mammals. Emerging links have revealed interplay between circadian clocks and signaling networks in cancer. Understanding the cross-talk between the circadian clock and tumorigenesis is imperative for its prevention, management and development of effective treatment options. In this review, we summarize the role of the circadian clock in regulation of one important metabolic pathway, insulin/IGF1/PI3K/mTOR signaling, and how dysregulation of this metabolic pathway could lead to uncontrolled cancer cell proliferation and growth. Targeting the circadian clock and rhythms either with recently discovered pharmaceutical agents or through environmental cues is a new direction in cancer chronotherapy. Combining the circadian approach with traditional methods, such as radiation, chemotherapy or the recently developed, immunotherapy, may improve tumor response, while simultaneously minimizing the adverse effects commonly associated with cancer therapies.
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昼夜节律时钟控制脓毒症中的免疫检查点通路
影响因子：
8.8
作者：
Deng W;Zhu S;Zeng L;Liu J;Kang R;Yang M;Cao L;Wang H;Billiar TR;Jiang J;Xie M;Tang D
通讯作者：
Tang D
影响因子：
16.2
作者：
Cao R;Robinson B;Xu H;Gkogkas C;Khoutorsky A;Alain T;Yanagiya A;Nevarko T;Liu AC;Amir S;Sonenberg N
通讯作者：
Sonenberg N
DOI：
10.1073/pnas.1619320114
发表时间：
2017-05-16
影响因子：
11.1
作者：
Anafi, Ron C.;Francey, Lauren J.;Kim, Junhyong
通讯作者：
Kim, Junhyong
卡路里限制对基因表达中昼夜节律的影响是性别依赖性的。
影响因子：
4.6
作者：
Astafev AA;Patel SA;Kondratov RV
通讯作者：
Kondratov RV
影响因子：
5.5
作者：
Altman BJ
通讯作者：
Altman BJ