Is Alzheimer's disease a systemic disease?
Is Alzheimer's disease a systemic disease?
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DOI：
10.1016/j.bbadis.2014.04.012
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发表时间：
2014-09
影响因子：
6.2
通讯作者：
Burns, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Morris, Jill K.;Honea, Robyn A.;Vidoni, Eric D.;Swerdlow, Russell H.;Burns, Jeffrey M.
虽然阿尔茨海默病（AD）是最常见的神经退行性疾病，但其病因尚不清楚。在某些情况下，遗传因素可以解释阿尔茨海默病的风险，但很大比例的迟发性阿尔茨海默病是无法解释的。阿尔茨海默病与许多身体和全身表现相关的事实表明，阿尔茨海默病是一种影响中枢神经系统和外周神经系统的多因素疾病。有趣的是，与AD相关的许多系统过程的一个共同特征是参与能量代谢。本综述的目的是：1)探索外周过程导致AD风险的证据；2)探索AD调节全身变化的途径；3)讨论遗传、线粒体和血管机制作为可能介导AD中枢和外周表现的潜在因素的作用。尽管努力将AD严格定义为一种同质的中枢神经系统疾病，但可能没有单一的病因途径导致AD痴呆综合征。相反，神经退行性过程可能涉及某种程度的基线遗传风险，该风险被外部风险因素修改。继续研究与阿尔茨海默病风险相关的多种相关过程对于成功开发疾病修饰疗法是必要的。
Although Alzheimer’s Disease (AD) is the most common neurodegenerative disease, the etiology of AD is not well understood. In some cases, genetic factors explain AD risk, but a high percentage of late-onset AD is unexplained. The fact that AD is associated with a number of physical and systemic manifestations suggests that AD is a multifactorial disease that affects both the CNS and periphery. Interestingly, a common feature of many systemic processes linked to AD is involvement in energy metabolism. The goals of this review are to 1) explore the evidence that peripheral processes contribute to AD risk, 2) explore ways that AD modulates whole-body changes, and 3) discuss the role of genetics, mitochondria, and vascular mechanisms as underlying factors that could mediate both central and peripheral manifestations of AD. Despite efforts to strictly define AD as a homogeneous CNS disease, there may be no single etiologic pathway leading to the syndrome of AD dementia. Rather, the neurodegenerative process may involve some degree of baseline genetic risk that is modified by external risk factors. Continued research into the diverse but related processes linked to AD risk is necessary for successful development of disease –modifying therapies.
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影响因子：
9.9
作者：
Burns JM;Cronk BB;Anderson HS;Donnelly JE;Thomas GP;Harsha A;Brooks WM;Swerdlow RH
通讯作者：
Swerdlow RH
影响因子：
11.4
作者：
Area-Gomez, Estela;Castillo, Maria Del Carmen Lara;Tambini, Marc D.;Guardia-Laguarta, Cristina;de Groof, Ad J. C.;Madra, Moneek;Ikenouchi, Junichi;Umeda, Masato;Bird, Thomas D.;Sturley, Stephen L.;Schon, Eric A.
通讯作者：
Schon, Eric A.
影响因子：
6.6
作者：
Bruce-Keller, Annadora J.;Gupta, Sunita;Markesbery, William R.
通讯作者：
Markesbery, William R.
影响因子：
9.9
作者：
Buchman, A. S.;Schneider, J. A.;Bennett, D. A.
通讯作者：
Bennett, D. A.
影响因子：
2.5
作者：
BRUEL, A;CHERQUI, G;DELABAR, J
通讯作者：
DELABAR, J