Noninvasive brain stimulation in the treatment of functional urological and pelvic floor disorders: A scoping review.
Noninvasive brain stimulation in the treatment of functional urological and pelvic floor disorders: A scoping review.
复制标题
无创脑刺激治疗功能性泌尿科和盆底疾病：范围界定审查。
DOI：
10.1002/nau.25205
复制
发表时间：
2023
影响因子：
2
通讯作者：
Khavari,Rose
中科院分区：
文献类型：
--
作者：
Mazeaud,Charles;Salazar,BetsyH;Khavari,Rose
功能性骨盆底疾病（PFD），如肠道和膀胱功能障碍，可以是具有挑战性的管理与我们目前的治疗方式。最近，非侵入性脑刺激已成为一种新的战略，非侵入性骨盆底管理。在这里，我们评估了关于这个主题的研究现状。方法通过Pubmed，Web of Science和Embase结合www.example.com进行范围审查clinicaltrials.gov，包括截至2022年6月30日的所有未超过时间限制的手稿。结果在由两名评审员盲选的880篇摘要中，14篇证据等级为1或2（牛津量表）的出版物合格并纳入本综述。排除综述文章、病例报告（<5例患者）、信件和方案研究。PFDs被描述为盆腔疼痛或下尿路症状（LUTS），重复经颅磁刺激（rTMS）是最常见的治疗方式。尽管治疗方案不同，但观察到显著改善，如排尿后残余尿减少，膀胱容量增加，排尿流量参数改善，慢性盆腔和膀胱疼痛减少。未观察到明显的不良反应。然而，低样本人群只允许临时conclusion.ConclusionNoninvasive经颅神经刺激LUTS和骨盆疼痛正在成为一个有效的工具，临床医生在未来利用。需要进一步的研究来阐明所示结果的全部意义。
IntroductionFunctional pelvic floor disorders (PFD) such as bowel and bladder dysfunctions can be challenging to manage with our current therapeutic modalities. Recently, noninvasive brain stimulation has emerged as a novel strategy for noninvasive pelvic floor management. Here, we assessed the current state of research on this topic.MethodsA scoping review was conducted with Pubmed, Web of Science, and Embase, in conjunction with clinicaltrials.gov, encompassing all manuscripts published without past time limit up until June 30, 2022.ResultsOf the 880 abstracts identified in a blind selection by two reviewers, 14 publications with an evidence level of 1 or 2 (Oxford scale) were eligible and included in this review. Review articles, case reports (<5 patients), letters, and protocol studies were excluded. PFDs were described as either pelvic pain or lower urinary tracts symptoms (LUTS) with repeated transcranial magnetic stimulation (rTMS) as the most common treatment modality. Despite heterogeneous therapeutic protocols, significant improvements were observed such as reduction in postvoid residual of urine, increased bladder capacity, improved voiding flow paraments, and decreased chronic pelvic, and bladder pain. No appreciable adverse effects were noted. However, low sample populations allowed only provisional conclusions.ConclusionNoninvasive transcranial neurostimulation for LUTS and pelvic pain is emerging as an effective tool for clinicians to utilize in the future. Further investigation is needed to elucidate the full significance of the indicated outcomes.
登录
查看更多内容
老年小鼠淋巴细胞上主要组织相容性复合物抗原的表达增加。
DOI：
10.1073/pnas.84.21.7624
发表时间：
1987
影响因子：
11.1
作者：
C. Sidman;E. Luther;J. D. Marshall;Kim;D. Roopenian;S. M. Worthen
通讯作者：
S. M. Worthen
选择产生高或低多特异性抗体的小鼠间系杂交中免疫反应性、寿命和疾病发生率的遗传。
影响因子：
4.4
作者：
V. Covelli;D. Mouton;V. di Majo;Y. Bouthillier;C. Bangrazi;J. Mével;S. Rebessi;G. Doria;G. Biozzi
通讯作者：
G. Biozzi
BALB/C 小鼠细胞介导免疫的年龄相关变化。
影响因子：
4.4
作者：
C. Walters;H. Claman
通讯作者：
H. Claman
衰老小鼠对刀豆球蛋白 A 和脂多糖的体外反应减少：反应细胞数量减少的作用
影响因子：
5.4
作者：
C. Abraham;Y. Tal;H. Gershon
通讯作者：
H. Gershon
年轻成年和老年小鼠腹膜巨噬细胞的抗原呈递。
影响因子：
4.3
作者：
Eugene H. Perkins;Joanne M. Massucci;Paul L. Glover
通讯作者：
Paul L. Glover