Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder.
Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder.
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肠道菌群相关炎症因子作为诊断重度抑郁症的潜在生物标志物
DOI：
10.3389/fcimb.2022.831186
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发表时间：
2022
影响因子：
5.7
通讯作者：
Chen JJ
中科院分区：
文献类型：
--
作者：
Bai S;Bai H;Li D;Zhong Q;Xie J;Chen JJ
虽然已经做了许多工作，但客观测量的诊断性生物标志物尚不可用。因此，我们进行了这项研究，以确定客观诊断抑郁症的潜在生物标志物，并探索肠道微生物群在抑郁症发病中的作用。重度抑郁症（MDD）患者（n=56）和人口统计学数据匹配的健康对照（HCs） （n=56）被纳入本研究。测定粪便样品中的肠道微生物群和血清中的炎症相关因子。进行单变量和多变量统计分析，以确定不同的肠道微生物群和炎症相关因素。最后，确定了46个差异操作分类单元（otu） （60.9% otu属于厚壁菌门）和10个差异炎症相关因子。相关分析显示，14个差异OTUs（厚壁菌门9个，厚壁菌门下毛缕菌科5个）与7个差异炎症相关因子存在显著相关性。同时，14个差异OTUs（9个属于厚壁菌门，5个属于厚壁菌门）和5个差异炎症相关因子（脂联素、载脂蛋白A1、α 1-抗胰蛋白酶、中性粒细胞计数/白细胞计数和嗜碱性粒细胞计数）与抑郁严重程度显著相关。由这五种不同的炎症相关因素组成的小组可以有效地从hcc诊断MDD患者。我们的研究结果表明厚壁菌门，特别是毛螺科，可能通过影响宿主的炎症水平在抑郁症的发病中发挥作用，这五个与炎症相关的差异因素可能是客观诊断MDD的潜在生物标志物。
Although many works have been done, the objectively measured diagnostic biomarkers are not available. Thus, we conducted this study to identify potential biomarkers for objectively diagnosing depression and explore the role of gut microbiota in the onset of depression. Major depressive disorder (MDD) patients (n=56) and demographic data-matched healthy controls (HCs) (n=56) were included in this study. The gut microbiota in fecal samples and inflammation-related factors in serum were measured. Both univariate and multivariate statistical analyses were performed to identify the differential gut microbiota and inflammation-related factors. Finally, 46 differential operational taxonomic units (OTUs) (60.9% OTUs belonging to Firmicutes) and ten differential inflammation-related factors were identified. Correlation analysis showed that there were significant correlations between 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and seven differential inflammation-related factors. Meanwhile, 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and five differential inflammation-related factors (adiponectin, apolipoprotein A1, alpha 1-antitrypsin, neutrophilicgranulocyte count/white blood cell count and basophil count) were significantly correlated to depression severity. A panel consisting of these five differential inflammation-related factors could effectively diagnose MDD patients from HCs. Our results suggested that Firmicutes, especially family Lachnospiraceae, might play a role in the onset of depression via affecting the inflammation levels of host, and these five differential inflammation-related factors could be potential biomarkers for objectively diagnosing MDD.
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影响因子：
6.6
作者：
Hidaka, Brandon H.
通讯作者：
Hidaka, Brandon H.
肠道微生物群衍生的炎症相关血清代谢物作为重度抑郁症的潜在生物标志物
影响因子：
4.5
作者：
Bai S;Xie J;Bai H;Tian T;Zou T;Chen JJ
通讯作者：
Chen JJ
通过整合蛋白质组学和代谢组学，磷脂代谢对主要抑郁症的血浆紊乱。
影响因子：
3.2
作者：
Gui SW;Liu YY;Zhong XG;Liu X;Zheng P;Pu JC;Zhou J;Chen JJ;Zhao LB;Liu LX;Xu G;Xie P
通讯作者：
Xie P
影响因子：
3.2
作者：
Chen JJ;Zheng P;Liu YY;Zhong XG;Wang HY;Guo YJ;Xie P
通讯作者：
Xie P
影响因子：
10.7
作者：
Khan, Imran;Pathan, Sabrina;Hsiao, W. L. Wendy
通讯作者：
Hsiao, W. L. Wendy