Signaling mechanisms controlling cell fate and embryonic patterning.
Signaling mechanisms controlling cell fate and embryonic patterning.
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DOI：
10.1101/cshperspect.a005975
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发表时间：
2012-08-01
影响因子：
7.2
通讯作者：
Shilo BZ
中科院分区：
文献类型：
--
作者：
Perrimon N;Pitsouli C;Shilo BZ
在发育过程中，信号通路通过响应细胞外信号激活转录程序来指定细胞命运。过去 30 年的大量研究表明，令人惊讶的是，调节发育程序的途径很少，而这些途径的失调可能导致包括癌症在内的人类疾病。尽管这些途径使用不同的信号成分和信号策略，但在时间和空间上的组织和调节方面出现了许多共同的主题。果蝇的例子，例如 Notch、Hedgehog、Wingless/WNT、BMP（骨形态发生蛋白）、EGF（表皮生长因子）和 FGF（成纤维细胞生长因子）信号传导，说明了它们在短距离或长距离内发挥作用的能力，并且在某些情况下产生形态发生素梯度，以浓度依赖性方式对细胞场进行图案化。他们还展示了反馈循环和转录级联如何成为发育调节逻辑的一部分。
During development, signaling pathways specify cell fates by activating transcriptional programs in response to extracellular signals. Extensive studies in the past 30 years have revealed that surprisingly few pathways exist to regulate developmental programs and that dysregulation of these can lead to human diseases, including cancer. Although these pathways use distinct signaling components and signaling strategies, a number of common themes have emerged regarding their organization and regulation in time and space. Examples from Drosophila, such as Notch, Hedgehog, Wingless/WNT, BMP (bone morphogenetic proteins), EGF (epidermal growth factor), and FGF (fibroblast growth factor) signaling, illustrate their abilities to act either at a short range or over a long distance, and in some instances to generate morphogen gradients that pattern fields of cells in a concentration-dependent manner. They also show how feedback loops and transcriptional cascades are part of the logic of developmental regulation.
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