Indocyanine green-assisted internal limiting membrane peeling in macular hole surgery: a meta-analysis.
Indocyanine green-assisted internal limiting membrane peeling in macular hole surgery: a meta-analysis.
复制标题
吲哚菁绿辅助黄斑裂孔手术中的内界膜剥离：一项荟萃分析。
DOI：
10.1371/journal.pone.0048405
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Yu J
中科院分区：
文献类型：
--
作者：
Wu Y;Zhu W;Xu D;Li YH;Ba J;Zhang XL;Wang F;Yu J
关于吲哚菁绿（ICG）在黄斑裂孔手术中应用的观点是相互矛盾的。在这里，我们进行了一项荟萃分析来评估内界膜（ILM）剥离对黄斑裂孔手术的效果。我们在电子数据库中检索了 2012 年 7 月之前发表的使用和不使用 ICG 的 ILM 剥离的比较研究。纳入 22 项研究，包括 1585 只眼睛。视力（VA）改善，包括术后VA增加率≥20/40（OR，0.65；95% CI，0.43至0.97；P = 0.033）和LogMAR增加（WMD，-0.09；95% CI，-0.16至-0.02；P = 0.011），在ICG组。 ICG 组视野缺损的风险高于非 ICG 组。使用和不使用 ICG 进行的 ILM 剥离手术之间的解剖结果率没有显着差异。 ICG 组和非 ICG 组之间 RPE 变化和其他术后并发症没有显着差异。另一项分析显示，仅在随访的第一年内，ICG 组的 VA 改善程度低于非 ICG 组。亚组分析显示，ICG 组的视力改善率低于其他辅助组。在 ICG 组中，较高比例 (>0.1%) 的二次闭合率较高，视力改善较少。从荟萃分析中排除随机对照试验后的敏感性分析表明，与总体结果相比没有差异。这项荟萃分析表明，没有证据表明 ICG 辅助 ILM 剥离手术的结果优于非 ICG 手术。选择各种染色方法时应考虑ICG的毒性。
The opinion of application of indocyanine green (ICG) in the macular hole surgery was contradictory. Here we conducted a meta-analysis to evaluate the effect of in internal limiting membrane (ILM) peeling for macular hole surgery. We searched electronic databases for comparative studies published before July 2012 of ILM peeling with and without ICG. Twenty-two studies including 1585 eyes were included. Visual acuity (VA) improvement, including the postoperative rate of ≥20/40 VA gained (OR, 0.65; 95% CI, 0.43 to 0.97; P = 0.033) and increased LogMAR (WMD, −0.09; 95% CI, −0.16 to −0.02; P = 0.011), was less in the ICG group. The risk of visual field defects was greater in the ICG group than in the non-ICG group. There was no significant difference in the rate of anatomical outcomes between ILM peeling procedures performed with and without ICG. RPE changes and other postoperative complications were not significantly different between the ICG and non-ICG groups. An additional analysis showed that the VA improvement of the ICG group was less than the non-ICG group only within the first year of follow up. A subgroup analysis showed that the rate of VA improvement was lower in the ICG group than in other adjuncts group. A higher rate of secondary closure and less VA improvement were observed in a high proportion (>0.1%) of the ICG group. A sensitivity analysis after the randomized-controlled trials were excluded from the meta-analysis demonstrated no differences compared with the overall results. This meta-analysis demonstrated that there is no evidence of clinical superiority in outcomes for ICG-assisted ILM peeling procedure over the non-ICG one. The toxicity of ICG should be considered when choosing the various staining methods.
登录
查看更多内容
影响因子：
4.2
作者：
Gandorfer, A;Messmer, EM;Kampik, A
通讯作者：
Kampik, A
影响因子：
6.3
作者：
Downs, SH;Black, N
通讯作者：
Black, N
DOI：
10.1097/iae.0b013e31822a33d0
发表时间：
2011-09-01
影响因子：
3.3
作者：
Fukuda, Kouki;Shiraga, Fumio;Ishibashi, Tatsuro
通讯作者：
Ishibashi, Tatsuro
影响因子：
4.2
作者：
Haritoglou, C;Neubauer, AS;Kampik, A
通讯作者：
Kampik, A
影响因子：
2.6
作者：
Brockmann, Tobias;Steger, Claudia;Dawczynski, Jens
通讯作者：
Dawczynski, Jens