Maternal Childhood Adversity Associates With Frontoamygdala Connectivity in Neonates.
Maternal Childhood Adversity Associates With Frontoamygdala Connectivity in Neonates.
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DOI：
10.1016/j.bpsc.2020.11.003
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Brennan PA
中科院分区：
文献类型：
--
作者：
Hendrix CL;Dilks DD;McKenna BG;Dunlop AL;Corwin EJ;Brennan PA
众所周知，暴露于逆境，特别是在敏感的发展时期，如童年，既有行为（例如，增加患精神疾病的风险）和神经生物学后果。但是，这些早期生活中暴露于逆境的影响也会代代相传吗？在这里，我们直接解决这个问题，调查母亲暴露于逆境在她自己的童年和她的新生儿的神经连接之间的关联。一个黑人母亲-新生儿二元组的样本（n = 48）--一个受早期生活逆境影响不成比例的群体--完成了评估他们目前痛苦的问卷（即，焦虑，抑郁和感知压力的综合措施）在怀孕的第一个和第三个三个月，并回顾性地报告了自己的童年经历的虐待和忽视。在产后一个月，这些妇女的新生儿后代在自然睡眠中完成了静息状态fMRI扫描。更大的母亲暴露在她自己的童年与更强的功能连接的两个不同的额杏仁核电路在这些新生儿，早在出生后一个月。这种影响是特定的情感忽视的早期经验，并没有解释母亲暴露于其他形式的儿童虐待或母亲痛苦在怀孕期间。这些结果提供了新的证据，表明母亲生命早期和怀孕前几年缺乏情感支持与她出生后不久的后代的神经变化有关-即杏仁核和内侧前额叶区域之间的功能连接。
It is well established that exposure to adversity, especially during sensitive periods of development such as childhood, has both behavioral (e.g., increasing one’s risk for psychiatric illnesses) and neurobiological consequences. But could these effects of early life exposure to adversity also be transmitted across generations? Here we directly address this question, investigating the associations between maternal exposure to adversity during her own childhood and neural connectivity in her neonate. A sample of Black mother-neonate dyads (n=48) – a group that is disproportionately affected by early life adversity – completed questionnaires assessing their current distress (i.e., a composite measure of anxiety, depression, and perceived stress) during the first and third trimesters of pregnancy and retrospectively reported on their own childhood experiences of abuse and neglect. At one-month postpartum, neonatal offspring of these women completed a resting-state fMRI scan during natural sleep. Greater maternal exposure to emotional neglect during her own childhood correlated with stronger functional connectivity of two different frontoamygdala circuits in these neonates, as early as one month after birth. This effect was specific to early experiences of emotional neglect and was not explained by maternal exposure to other forms of childhood maltreatment or maternal distress during pregnancy. These results provide novel evidence that the absence of emotional support early in a mother’s life, and years before conception, are associated with neural changes – namely, in functional connectivity between amygdala and medial prefrontal regions – in her offspring shortly after birth.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
26.1
作者：
Bick, Johanna;Zhu, Tong;Stamoulis, Catherine;Fox, Nathan A.;Zeanah, Charles;Nelson, Charles A.
通讯作者：
Nelson, Charles A.
影响因子：
3.7
作者：
Bierer, Linda M.;Bader, Heather N.;Yehuda, Rachel
通讯作者：
Yehuda, Rachel
DOI：
10.1073/pnas.1307893110
发表时间：
2013-09-24
影响因子：
11.1
作者：
Gee, Dylan G.;Gabard-Durnam, Laurel J.;Tottenham, Nim
通讯作者：
Tottenham, Nim
影响因子：
5
作者：
Callaghan BL;Tottenham N
通讯作者：
Tottenham N