Experimental and finite element analysis of strains induced by axial tibial compression in young-adult and old female C57Bl/6 mice.
Experimental and finite element analysis of strains induced by axial tibial compression in young-adult and old female C57Bl/6 mice.
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DOI：
10.1016/j.jbiomech.2013.10.052
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发表时间：
2014-01-22
影响因子：
2.4
通讯作者：
Silva, Matthew J.
中科院分区：
文献类型：
--
作者：
Patel, Tarpit K.;Brodt, Michael D.;Silva, Matthew J.
采用小鼠胫骨的轴向压缩模型，研究了应变适应性骨模型。在一些研究中，不同年龄的小鼠之间的比较是有意义的。我们研究了5个月、12个月和22个月龄的雌性C57BL/6小鼠的胫骨变形和力-应变关系。采用三规实验法测定骨干中段的应变分布，采用特定试件的有限元分析方法研究胫骨长度方向的应变分布。胫骨中骨干横断面的峰值应变为压缩应变，出现在后外侧尖端。这些峰值压缩应变的大小是相对的前内侧表面(一个经常用于放置应变计的位置)的1.5到2倍。例如，−10 N力作用于一只5个月大的小鼠，其峰值压缩应变为−2800με，前内侧面上的拉伸应变为+1450με。中性轴在胫骨中段的方向与年龄无明显差异(p=0.46)，表明青年和老年胫骨具有相似的变形方式。另一方面，从5个月到22个月，皮质厚度和转动惯量减少了25%(p<；0.05)，导致在同等作用力下，老年小鼠的胫骨应变幅度显著增加(p<；0.05)。我们的结论是，青年-成人和老年C57BL/6胫骨的胫骨负荷响应的比较是由于相似的年龄变形模式所致，但需要适度调整力水平以产生匹配的峰值应变。
Axial compression of the mouse tibia is used to study strain-adaptive bone (re)modeling. In some studies, comparisons between mice of different ages are of interest. We characterized the tibial deformation and force–strain relationships in female C57Bl/6 mice at 5-, 12- and 22-months age. A three-gauge experimental method was used to determine the strain distribution at the mid-diaphysis, while specimen-specific finite element analysis was used to examine strain distribution along the tibial length. The peak strains in the tibial mid-diaphyseal cross-section are compressive and occur at the postero-lateral apex. The magnitudes of these peak compressive strains are 1.5 to 2 times those on the opposite, antero-medial face (a site often used for strain gauge placement). For example, −10 N force applied to a 5-months old mouse engenders a peak compressive strain of −2800 με and a tensile strain on the antero-medial face of +1450 με. The orientation of the neutral axis at the mid-diaphysis did not differ with age (p=0.46), indicating a similar deformation mode in young and old tibiae. On the other hand, from 5- to 22-months there is a 25% reduction in cortical thickness and moment of inertia (p < 0.05), resulting in significantly greater tibial strain magnitudes in older mice for equivalent applied force (p < 0.05). We conclude that comparisons of tibial loading responses in young-adult and old C57Bl/6 tibiae are facilitated by similar deformation pattern across ages, but that modest adjustment of force levels is required to engender matching peak strains.
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影响因子：
4.1
作者：
Lynch, Maureen E.;Main, Russell P.;Xu, Qian;Schmicker, Thomas L.;Schaffler, Mitchell B.;Wright, Timothy M.;van der Meulen, Marjolein C. H.
通讯作者：
van der Meulen, Marjolein C. H.
影响因子：
3.3
作者：
Lynch, Maureen E.;Main, Russell P.;van der Meulen, Marjolein C. H.
通讯作者：
van der Meulen, Marjolein C. H.
影响因子：
2.4
作者：
Kotha, SP;Hsieh, YF;Silva, MJ
通讯作者：
Silva, MJ
小鼠的受限胫骨振动：一种研究骨振动载荷影响的方法。
DOI：
10.1115/1.2917435
发表时间：
2008-08
影响因子：
1.7
作者：
Christiansen, Blaine A.;Bayly, Philip V.;Silva, Matthew J.
通讯作者：
Silva, Matthew J.
影响因子：
4
作者：
Moustafa, A.;Sugiyama, T.;Prasad, J.;Zaman, G.;Gross, T. S.;Lanyon, L. E.;Price, J. S.
通讯作者：
Price, J. S.