Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer.
Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer.
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掺入黑磷的水凝胶作为可喷涂和可生物降解的光热平台，用于癌症术后治疗
DOI：
10.1002/advs.201700848
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Yu XF
中科院分区：
文献类型：
--
作者：
Shao J;Ruan C;Xie H;Li Z;Wang H;Chu PK;Yu XF
光热疗法（PTT）是一种用于具有最小侵入性的癌症治疗的新兴治疗策略，但临床采用受到诸如PTT试剂的生物降解性不足和缺乏有效递送系统等问题的抑制。在这里，黑磷（BP）纳米片与热敏水凝胶[聚（d，l-丙交酯）-聚（乙二醇）-聚（d，l-丙交酯）（PDLLA-PEG-PDLLA：PLEL）]结合，以产生用于癌症术后治疗的新PTT系统。BP@PLEL水凝胶具有优异的近红外（NIR）光热性能和快速的NIR诱导溶胶-凝胶转变，以及良好的体外和体内生物降解性和生物相容性。基于这些优点，建立了体内PTT术后治疗策略。在NIR照射下，喷涂的BP@PLEL水凝胶能够在伤口上快速凝胶化形成凝胶膜，并提供高PTT功效以消除肿瘤切除手术后的残留肿瘤组织。此外，良好的光热抗菌性能可以防止感染，这种高效和可生物降解的PTT系统在癌症术后治疗中非常有前景。
Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack of an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated with a thermosensitive hydrogel [poly(d,l‐lactide)‐poly(ethylene glycol)‐poly(d,l‐lactide) (PDLLA‐PEG‐PDLLA: PLEL)] to produce a new PTT system for postoperative treatment of cancer. The BP@PLEL hydrogel exhibits excellent near infrared (NIR) photothermal performance and a rapid NIR‐induced sol–gel transition as well as good biodegradability and biocompatibility in vitro and in vivo. Based on these merits, an in vivo PTT postoperative treatment strategy is established. Under NIR irradiation, the sprayed BP@PLEL hydrogel enables rapid gelation forming a gelled membrane on wounds and offers high PTT efficacy to eliminate residual tumor tissues after tumor removal surgery. Furthermore, the good photothermal antibacterial performance prevents infection and this efficient and biodegradable PTT system is very promising in postoperative treatment of cancer.
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DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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影响因子：
29.4
作者：
Chen, Long;Zhou, Guangmin;Ren, Wencai
通讯作者：
Ren, Wencai
影响因子：
16.6
作者：
Doganov, Rostislav A.;O'Farrell, Eoin C. T.;Ozyilmaz, Barbaros
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