The magnetophoretic mobility and superparamagnetism of core-shell iron oxide nanoparticles with dual targeting and imaging functionality.
The magnetophoretic mobility and superparamagnetism of core-shell iron oxide nanoparticles with dual targeting and imaging functionality.
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DOI：
10.1016/j.biomaterials.2010.03.072
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发表时间：
2010-08
期刊：
影响因子：
14
通讯作者：
Yang, Victor C.
中科院分区：
文献类型：
--
作者：
Yu, Faquan;Zhang, Lei;Huang, Yongzhuo;Sun, Kai;David, Allan E.;Yang, Victor C.
为了实现高效的 MRI 监测磁靶向，合成了一种具有优异磁泳迁移率和超顺磁性双重性质的新型药物载体。该载体专门设计为核壳结构。该核心是通过利用先前制备的带相反电荷的超细超顺磁性氧化铁纳米颗粒的自组装策略来实现的。最终的颗粒是通过用羧甲基葡聚糖（CMD）聚合物涂覆这些核心而形成的。通过从颗粒内部排除非磁性材料，这种结构最大限度地增加了磁性材料的量，从而产生了优异的磁泳迁移率。这种策略避免了超顺磁性损失的挑战，这种损失可能是由于核心超过临界域尺寸而引起的。涂覆自组装核心使磁性载体在使用和储存时保持稳定，并易于与药物分子连接以用于治疗应用。体外表征表明，与传统的基于氧化铁的磁性纳米颗粒相比，这些纳米颗粒的磁泳迁移率提高了 3 至 4 倍，并且在 50% 血清中储存时稳定性显着提高。初步体内研究表明，纳米颗粒还可以作为脑胶质瘤 MR 成像的对比增强剂。这项技术可能会导致磁性载体新范例的开发，以满足各种临床应用的需求。
With the goal to achieve highly efficacious MRI-monitored magnetic targeting, a novel drug carrier with dual nature of superior magnetophoretic mobility and superparamagnetism was synthesized. This carrier was specially designed in a core-shell structure. The core was achieved by utilizing a strategy of self-assembly of oppositely charged ultrafine superparamagnetic iron oxide nanoparticles previously prepared. The final particles were formed by coating such cores with carboxymethyldextran (CMD) polymer. By exclusion of non-magnetic materials from the interior part of the particles, this structure maximized the amount of magnetic material and thus yielded a superior magnetophoretic mobility. Such a strategy avoids the challenge of superparamagnetism loss, which would be caused by cores exceeding a critical domain size. Coating the self-assembled core enables the magnetic carrier to be stable upon usage and storage and to be readily linked with drug molecules for therapeutic applications. In vitro characterization showed that these nanoparticles displayed a 3- to 4-fold enhancement in magnetophoretic mobility, and a markedly improved stability when stored in 50% serum as a comparison of conventional iron oxide-based magnetic nanoparticles. Preliminary in vivo studies revealed that the nanoparticles alsofunction well as a contrast enhancer for MR imaging of brain glioma. This technology could lead to the development of a new paradigm of magnetic carriers that meet with the needs of various clinical applications.
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影响因子：
4.9
作者：
Yu, Faquan;Yang, Victor C.
通讯作者：
Yang, Victor C.
DOI：
10.2217/17435889.3.5.703
发表时间：
2008-10
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Longmire M;Choyke PL;Kobayashi H
通讯作者：
Kobayashi H
影响因子：
64.8
作者：
HINGSTON, FJ;ATKINSON, RJ;QUIRK, JP
通讯作者：
QUIRK, JP
DOI：
10.1080/10826079608005537
发表时间：
1996-01-01
影响因子：
1.3
作者：
Fauconnier, N;Bee, A;Dardoize, F
通讯作者：
Dardoize, F
影响因子：
3.9
作者：
Laaksonen, Paivi;Kivioja, Jani;Linder, Markus B.
通讯作者：
Linder, Markus B.