Adolescent behavior and dopamine availability are uniquely sensitive to dietary omega-3 fatty acid deficiency.
Adolescent behavior and dopamine availability are uniquely sensitive to dietary omega-3 fatty acid deficiency.
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DOI：
10.1016/j.biopsych.2013.06.007
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发表时间：
2014-01-01
影响因子：
10.6
通讯作者：
Moghaddam, Bita
中科院分区：
文献类型：
--
作者：
Bondi, Corina O.;Taha, Ameer Y.;Tock, Jody L.;Totah, Nelson K. B.;Cheon, Yewon;Torres, Gonzalo E.;Rapoport, Stanley I.;Moghaddam, Bita
了解影响行为健康的环境因素的本质对于有精神疾病风险的个体的成功预防策略至关重要。这些因素在本质上是典型的经验因素，如压力和城市化，但营养，特别是饮食中缺乏omega-3多不饱和脂肪酸（n-3 PUFAs），越来越多地与精神分裂症和情绪障碍的症状性发作有关，这些症状通常发生在青春期到成年早期。因此，青春期可能是饮食对环境造成负面影响的关键年龄段。一个涉及连续几代n-3多聚脂肪酸缺乏症的大鼠模型是基于这样的假设建立的：四五十年前，当当前青少年的父母出生时，饮食趋势就开始减少这些脂肪的摄入。研究人员比较了喂食n-3 PUFA充足和缺乏饮食的青少年和成年人在各种任务中的行为表现，以及多巴胺相关神经传递的标志物。在青少年中，连续几代的饮食n-3 PUFA缺乏会导致认知和动机行为的模式选择性和任务依赖性损伤，这与在成人中观察到的缺陷不同。虽然这种饮食不足影响了两个年龄组中多巴胺相关蛋白的表达，但在青少年中，而不是成年人，酪氨酸羟化酶的表达增加，这是对背纹状体的选择性表达。这些数据支持营养对青少年最佳认知和情感功能的贡献。此外，他们认为n-3 PUFA缺乏通过增强背纹状体多巴胺的可用性来破坏青少年的行为。
Understanding the nature of environmental factors that contribute to behavioral health is critical for successful prevention strategies in individuals at-risk for psychiatric disorders. These factors are typically experiential in nature, such as stress and urbanicity, but nutrition, in particular dietary deficiency of omega-3 polyunsaturated fatty acids (n-3 PUFAs), has increasingly been implicated in the symptomatic onset of schizophrenia and mood disorders, which typically occurs during adolescence to early adulthood. Thus, adolescence may be the critical age range for the negative impact of diet as an environmental insult. A rat model involving consecutive generations of n-3 PUFA deficiency was developed based on the assumption that dietary trends toward decreased consumption of these fats began four-five decades ago when the parents of current adolescents were born. Behavioral performance in a wide range of tasks, as well as markers of dopamine-related neurotransmission was compared in adolescents and adults fed n-3 PUFA adequate and deficient diets. In adolescents, dietary n-3 PUFA deficiency across consecutive generations produced a modality-selective and task-dependent impairment in cognitive and motivated behavior distinct from the deficits observed in adults. While this dietary deficiency affected expression of dopamine-related proteins in both age groups, in adolescents, but not adults, there was an increase in tyrosine hydroxylase expression that was selective to the dorsal striatum. These data support a nutritional contribution to optimal cognitive and affective functioning in adolescents. Furthermore, they suggest that n-3 PUFA deficiency disrupts adolescent behaviors through enhanced dorsal striatal dopamine availability.
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影响因子：
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影响因子：
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作者：
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