Amyloid Positivity Using [18F]Flutemetamol-PET and Cognitive Deficits in Nondemented Community-Dwelling Older Adults.
Amyloid Positivity Using [18F]Flutemetamol-PET and Cognitive Deficits in Nondemented Community-Dwelling Older Adults.
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DOI：
10.1177/1533317517698795
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Hoffman JM
中科院分区：
文献类型：
--
作者：
Hammers DB;Atkinson TJ;Dalley BCA;Suhrie KR;Horn KP;Rasmussen KM;Beardmore BE;Burrell LD;Duff K;Hoffman JM
Little research exists examining the relationship between beta-amyloid neuritic plaque density via [18F]flutemetamol binding and cognition; consequently, the purpose of the current study was to compare cognitive performances among individuals having either increased amyloid deposition (Flute+) or minimal amyloid deposition (Flute−). Twenty-seven nondemented community-dwelling adults over the age of 65 underwent [18F]flutemetamol amyloid-positron emission tomography imaging, along with cognitive testing using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and select behavioral measures. Analysis of variance was used to identify the differences among the cognitive and behavioral measures between Flute+/Flute− groups. Flute+ participants performed significantly worse than Flute− participants on RBANS indexes of immediate memory, language, delayed memory, and total scale score, but no significant group differences in the endorsed level of depression or subjective report of cognitive difficulties were observed. Although these results are preliminary, [18F]flutemetamol accurately tracks cognition in a nondemented elderly sample, which may allow for better prediction of cognitive decline in late life.
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DOI：
10.1007/s00259-015-3156-9
发表时间：
2016-01-01
影响因子：
9.1
作者：
Adamczuk, Katarzyna;Schaeverbeke, Jolien;Vandenberghe, Rik
通讯作者：
Vandenberghe, Rik
影响因子：
2.6
作者：
Amariglio RE;Becker JA;Carmasin J;Wadsworth LP;Lorius N;Sullivan C;Maye JE;Gidicsin C;Pepin LC;Sperling RA;Johnson KA;Rentz DM
通讯作者：
Rentz DM
影响因子：
105.7
作者：
Kaduszkiewicz, H;Zimmermann, T;van den Bussche, H
通讯作者：
van den Bussche, H
影响因子：
2.6
作者：
Duff, Kevin;Clark, Joy D. Humphreys;Sutker, Patricia B.
通讯作者：
Sutker, Patricia B.
使用 (18)F-氟替他莫进行淀粉样蛋白正电子发射断层扫描和结构磁共振成像对轻度认知障碍和阿尔茨海默病的分类。
DOI：
10.1016/j.jalz.2012.01.006
发表时间：
2013-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Duara R;Loewenstein DA;Shen Q;Barker W;Potter E;Varon D;Heurlin K;Vandenberghe R;Buckley C
通讯作者：
Buckley C