Brain Sex in Transgender Women Is Shifted towards Gender Identity.
Brain Sex in Transgender Women Is Shifted towards Gender Identity.
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DOI：
10.3390/jcm11061582
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发表时间：
2022-03-13
影响因子：
3.9
通讯作者：
Luders E
中科院分区：
文献类型：
--
作者：
Kurth F;Gaser C;Sánchez FJ;Luders E
变性人报告称，他们对出生时的性别感到不适，并强烈认同异性。目前的这项研究旨在进一步阐明变性人的大脑是否与他们出生时的性别或性别认同相似。为此，我们在性别肯定激素治疗前分析了24名顺性男性、24名顺性女性和24名变性人的样本。我们使用了一种最近开发的多元分类器，它可以为男性或女性的大脑产生连续的概率(而不是二进制)估计。变性女性的大脑介于顺性别男性和顺性别女性之间(尽管仍然更接近于顺性别男性)，而且对顺性别男性和顺性别女性的差异都是显著的(分别为p=0.016和p<；0.001)。这些发现支持这样一种观点，即变性人潜在的大脑解剖结构从他们的生物性别转移到了他们的性别认同。
Transgender people report discomfort with their birth sex and a strong identification with the opposite sex. The current study was designed to shed further light on the question of whether the brains of transgender people resemble their birth sex or their gender identity. For this purpose, we analyzed a sample of 24 cisgender men, 24 cisgender women, and 24 transgender women before gender-affirming hormone therapy. We employed a recently developed multivariate classifier that yields a continuous probabilistic (rather than a binary) estimate for brains to be male or female. The brains of transgender women ranged between cisgender men and cisgender women (albeit still closer to cisgender men), and the differences to both cisgender men and to cisgender women were significant (p = 0.016 and p < 0.001, respectively). These findings add support to the notion that the underlying brain anatomy in transgender people is shifted away from their biological sex towards their gender identity.
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