Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population.
Serological survey of neutralizing antibodies to eight major enteroviruses among healthy population.
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健康人群八种主要肠道病毒中和抗体血清学调查
DOI：
10.1038/s41426-017-0003-z
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发表时间：
2018-01-10
影响因子：
13.2
通讯作者：
Xia N
中科院分区：
文献类型：
--
作者：
Zhu R;Cheng T;Yin Z;Liu D;Xu L;Li Y;Wang W;Liu J;Que Y;Ye X;Tang Q;Zhao Q;Ge S;He S;Xia N
人类肠道病毒（Human enterovirus，EV）是人类最常见的病原体，可引起手足口病（hand，foot，and mouth disease，HFMD）、疱疹性咽峡炎（herpangina，HA）、心肌炎、脑炎、无菌性脑膜炎等多种疾病。EV相关疾病对全球公共卫生构成严重威胁。为了全面了解人类主要流行EV的血清流行病学，我们首先对肠道病毒A71（EV-A71）、科萨基病毒A16（CV-A16）、科萨基病毒A6（CV-A6）、科萨基病毒A10（CV-A10）、科萨基病毒B3（CV-B3）、科萨基病毒B5（CV-B5）、2016年厦门市健康人群中埃可病毒25（ECHO 25）和埃可病毒30（ECHO 30），采用微量中和试验。采用分层随机抽样的方法，共招募了515名年龄在5个月至83岁之间的受试者。大多数主要的人类EV在厦门市广泛传播，通常感染婴儿和儿童。这8种EV的总体血清阳性率范围为14.4%至42.7%，其中大多数随年龄增加而增加，随后达到平台。由于不同血清型EV的交替感染或合并感染，在≥ 7岁的人群中，多种EV的nAb共存是常见的，而大多数儿童，特别是< 1岁的儿童，对EV的nAb阴性。这是第一份详细描述同一人群中8种流行EV的血清流行病学报告，为进一步研究EV相关疾病的预防和控制提供了科学数据。
Human enteroviruses (EVs) are the most common causative agents infecting human, causing many harmful diseases, such as hand, foot, and mouth disease (HFMD), herpangina (HA), myocarditis, encephalitis, and aseptic meningitis. EV-related diseases pose a serious worldwide threat to public health. To gain comprehensive insight into the seroepidemiology of major prevalent EVs in humans, we firstly performed a serological survey for neutralizing antibodies (nAbs) against Enterovirus A71 (EV-A71), Coxsackie virus A16 (CV-A16), Coxsackie virus A6 (CV-A6), Coxsackie virus A10 (CV-A10), Coxsackie virus B3 (CV-B3), Coxsackie virus B5 (CV-B5), Echovirus 25 (ECHO25), and Echovirus 30 (ECHO30) among the healthy population in Xiamen City in 2016, using micro-neutralization assay. A total of 515 subjects aged 5 months to 83 years were recruited by stratified random sampling. Most major human EVs are widely circulated in Xiamen City and usually infect infants and children. The overall seroprevalence of these eight EVs were ranged from 14.4% to 42.7%, and most of them increased with age and subsequently reached a plateau. The co-existence of nAbs against various EVs are common among people ≥ 7 years of age, due to the alternate infections or co-infections with different serotypes of EVs, while most children were negative for nAb against EVs, especially those < 1 year of age. This is the first report detailing the seroepidemiology of eight prevalent EVs in the same population, which provides scientific data supporting further studies on the improvement of EV-related disease prevention and control.
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影响因子：
3.7
作者：
Li W;Yi L;Su J;Lu J;Zeng H;Guan D;Ma C;Zhang W;Xiao H;Li H;Zhang Y;Lin J;Ke C
通讯作者：
Ke C
DOI：
10.1016/b978-0-444-53488-0.00018-3
发表时间：
2014-01-01
期刊：
NEUROVIROLOGY
影响因子：
--
作者：
Jubelt, Burk;Lipton, Howard L.
通讯作者：
Lipton, Howard L.
DOI：
10.1056/nejmra0800028
发表时间：
2009-04-09
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cooper LT Jr
通讯作者：
Cooper LT Jr
华中地区手足口病大暴发期间柯萨奇病毒A16型和肠道病毒71型的共循环和基因组重组
影响因子：
3.7
作者：
Liu W;Wu S;Xiong Y;Li T;Wen Z;Yan M;Qin K;Liu Y;Wu J
通讯作者：
Wu J
影响因子：
4.2
作者：
He, S. Z.;Chen, M. Y.;Xia, N. S.
通讯作者：
Xia, N. S.