Rickettsia species in African Anopheles mosquitoes.
Rickettsia species in African Anopheles mosquitoes.
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DOI：
10.1371/journal.pone.0048254
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Raoult D
中科院分区：
文献类型：
--
作者：
Socolovschi C;Pages F;Ndiath MO;Ratmanov P;Raoult D
在撒哈拉以南非洲，发烧患者的费氏杆菌感染率高于健康人，主要是在雨季。蚊子具有很高的媒介能力，由于它们的丰度和攻击性，很可能在立克次体流行病学中发挥作用。针对立克次体基因的定量和传统聚合酶链式反应分析在从科特迪瓦、加蓬和塞内加尔收集的848只按蚊中检测到13只立克次体DNA(1.5%)。在1例AN中检出费氏乳杆菌。采自科特迪瓦卡欣的冈比亚按蚊的S分子分类(1/77，1.3%)。此外，在5个AN中检测到一种新的立克次体基因。采集自科特迪瓦的冈比亚按蚊S(5/77，6.5%)和加蓬利伯维尔的1只蚊子(1/88，1.1%)，以及6只按蚊。Melas(6/67，9%)从加蓬真蒂尔港采集的蚊子。对GLTA、ompB、OmpA和sca4基因的序列分析表明，该新立克次体是一种新的立克次体。与费氏乳杆菌有密切关系。未检测到立克次体DNA。Funestus，An.Arabiens，或An.冈比亚亚纲分子形成M型蚊子。此外，对新立克次体的GLTA序列进行了BLAST分析。与以前在基杜古地区班达法西村一名发烧的塞内加尔患者的血液样本中检测到的一种物种(JQ674485)的序列相似性为99.71%。费氏罗非氏菌是在我国首次发现。冈比亚分子形成S，代表非洲主要的疟疾媒介。在蚊子中发现费氏立克次体以及一个新的立克次体物种，对非洲立克次体流行病学提出了新的问题，需要进行调查，如细菌分离、蚊子媒介能力的程度、动物宿主和人类致病性。
There is higher rate of R. felis infection among febrile patients than in healthy people in Sub-Saharan Africa, predominantly in the rainy season. Mosquitoes possess a high vectorial capacity and, because of their abundance and aggressiveness, likely play a role in rickettsial epidemiology. Quantitative and traditional PCR assays specific for Rickettsia genes detected rickettsial DNA in 13 of 848 (1.5%) Anopheles mosquitoes collected from Côte d’Ivoire, Gabon, and Senegal. R. felis was detected in one An. gambiae molecular form S mosquito collected from Kahin, Côte d’Ivoire (1/77, 1.3%). Additionally, a new Rickettsia genotype was detected in five An. gambiae molecular form S mosquitoes collected from Côte d’Ivoire (5/77, 6.5%) and one mosquito from Libreville, Gabon (1/88, 1.1%), as well as six An. melas (6/67, 9%) mosquitoes collected from Port Gentil, Gabon. A sequence analysis of the gltA, ompB, ompA and sca4 genes indicated that this new Rickettsia sp. is closely related to R. felis. No rickettsial DNA was detected from An. funestus, An. arabiensis, or An. gambiae molecular form M mosquitoes. Additionally, a BLAST analysis of the gltA sequence from the new Rickettsia sp. resulted in a 99.71% sequence similarity to a species (JQ674485) previously detected in a blood sample of a Senegalese patient with a fever from the Bandafassi village, Kedougou region. R. felis was detected for the first time in An. gambiae molecular form S, which represents the major African malaria vector. The discovery of R. felis, as well as a new Rickettsia species, in mosquitoes raises new issues with respect to African rickettsial epidemiology that need to be investigated, such as bacterial isolation, the degree of the vectorial capacity of mosquitoes, the animal reservoirs, and human pathogenicity.
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影响因子：
11.8
作者：
Maina AN;Knobel DL;Jiang J;Halliday J;Feikin DR;Cleaveland S;Ng'ang'a Z;Junghae M;Breiman RF;Richards AL;Njenga MK
通讯作者：
Njenga MK
影响因子：
2.1
作者：
Hii, Sze Fui;Kopp, Steven R.;Traub, Rebecca J.
通讯作者：
Traub, Rebecca J.
立克的立克氏菌的基因组序列鉴定出强制性细胞内寄生虫中的第一个假定的共轭质粒。
影响因子：
9.8
作者：
Ogata H;Renesto P;Audic S;Robert C;Blanc G;Fournier PE;Parinello H;Claverie JM;Raoult D
通讯作者：
Raoult D
DOI：
10.1016/j.cimid.2011.11.007
发表时间：
2012-03-01
影响因子：
2
作者：
Khaldi, Mourad;Socolovschi, Cristina;Parola, Philippe
通讯作者：
Parola, Philippe
DOI：
10.1099/ijs.0.011049-0
发表时间：
2010-04-01
影响因子：
2.8
作者：
Duh, Darja;Punda-Polic, Volga;Strus, Jasna
通讯作者：
Strus, Jasna