Complex sensorimotor transformation processes required for response selection are facilitated by the striatum
Complex sensorimotor transformation processes required for response selection are facilitated by the striatum
复制标题
纹状体促进了反应选择所需的复杂感觉运动转换过程
DOI：
10.1016/j.neuroimage.2015.08.036
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发表时间：
2015
期刊：
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
额-顶网络和基底神经节在动作级联中都起着重要的作用。众所周知，皮层结构为此目的介导感觉运动转换。纹状体从这些皮质结构接收大量的输入，并且已经被证明是由皮质输入的可预测性调制的。然而，直到今天，空间代码的处理甚至是以动作级联为目的的感觉运动转换过程是否涉及纹状体仍然不清楚。因此，我们研究了这个问题，通过功能磁共振成像使用的停止变化的任务，不同的可预测性，以及所需的正确响应的上下文中的动作cascading.On的行为水平上，感觉运动转换过程的复杂性，我们发现，只有延长反应时间时，这种转换的要求是可预测的。功能磁共振成像结果与这种效应相匹配，显示在可以预期复杂的感觉运动转化的情况下尾状核的活动增强。不管所需的转换的复杂性，壳核进一步参与预测即将采取的行动级联的需求。两者合计，我们的研究结果引起了一个概念上的进步，关于基底神经节功能的预测，更重要的是，复杂的感觉运动转换过程的处理涉及纹状体。
Both fronto-parietal networks and the basal ganglia play an important role in action cascading. It is well-known that cortical structures mediate sensorimotor transformation for this purpose. The striatum receives extensive input from those cortical structures and has been shown to be modulated by the predictability of cortical input. Until today, it has however remained unclear whether the processing of spatial codes or even sensorimotor transformation processes for the purpose of action cascading involve the striatum. We therefore examined this question by means of fMRI using a stop-change task that varied the predictability as well as the complexity of sensorimotor transformations required for correct responding in the context of action cascading.On the behavioral level, we found that the complexity of sensorimotor transformation processes only prolonged reaction times when the requirement for this transformation was predictable. fMRI results matched this effect showing enhanced activity of the caudate in case a complex sensorimotor transformation could be anticipated. Irrespective of the complexity of the required transformations, the putamen was furthermore involved in the prediction of imminent action cascading demands. Taken together, our findings give rise to a conceptual advance regarding basal ganglia function by showing that the anticipation and, more importantly, processing of complex sensorimotor transformation processes involves the striatum.
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影响因子：
4.8
作者：
Yildiz, Ali;Quetscher, Clara;Dharmadhikari, Shalmali;Chmielewski, Witold;Glaubitz, Benjamin;Schmidt-Wilcke, Tobias;Edden, Richard;Dydak, Ulrike;Beste, Christian
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R. Cools
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Beste, Christian
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Fink, GR
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作者：
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通讯作者：
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