Divergence of fMRI and neural signals in V1 during perceptual suppression in the awake monkey.
Divergence of fMRI and neural signals in V1 during perceptual suppression in the awake monkey.
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在清醒猴子中，fMRI和神经信号的差异在V1中。
DOI：
10.1038/nn.2173
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发表时间：
2008-10
影响因子：
25
通讯作者：
Leopold, David A.
中科院分区：
文献类型：
--
作者：
Maier, Alexander;Wilke, Melanie;Aura, Christopher;Zhu, Charles;Ye, Frank Q.;Leopold, David A.
初级视觉皮质(V1)在决定知觉内容中的作用是有争议的。人类功能成像(FMRI)对知觉抑制的研究表明，当刺激在主观上不可见时，V1活动会显著下降。相比之下，猴子单一单位的录音未能证明这种感知锁定的变化在V1中。为了研究这种差异的基础，我们测量了两只行为猴子的血氧水平依赖(BOLD)反应和几个电生理信号。我们发现，在常规刺激呈现过程中，所有信号都表现出良好的一致性，表现出对呈现和去除刺激的强烈视觉调制。然而，在知觉抑制中，只有大胆反应和低频局域场势(LFP)信号表现出下降，而尖峰和高频局域场势(LFP)信号没有受到影响。这些结果表明，V1中BOLD和电生理信号之间的耦合是上下文相关的，在知觉抑制过程中发生了显著的分离。
The role of primary visual cortex (V1) in determining the contents of perception is controversial. Human functional imaging (fMRI) studies of perceptual suppression have revealed a robust drop in V1 activity when a stimulus is subjectively invisible. In contrast, monkey single unit recordings have failed to demonstrate such perception locked changes in V1. To investigate the basis of this discrepancy, we measured both the blood oxygenation level-dependent (BOLD) response and several electrophysiological signals in two behaving monkeys. We found that during conventional stimulus presentation, all signals were in good agreement, showing strong visual modulation to presentation and removal of a stimulus. However, during perceptual suppression, only the BOLD response and low frequency local field potential (LFP) signals exhibited decreases, while the spiking and high frequency LFP signals were unaffected. These results demonstrate that the coupling between the BOLD and electrophysiological signals in V1 is context dependent, with a marked dissociation occurring during perceptual suppression.
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影响因子：
16.2
作者：
Mitchell, Jude F.;Sundberg, Kristy A.;Reynolds, John H.
通讯作者：
Reynolds, John H.
影响因子：
9.2
作者：
Nir, Yuval;Fisch, Lior;Malach, Rafael
通讯作者：
Malach, Rafael
影响因子：
64.8
作者：
Leopold, DA;Logothetis, NK
通讯作者：
Logothetis, NK
影响因子：
3.3
作者：
GRUETTER, R
通讯作者：
GRUETTER, R
影响因子：
25
作者：
Polonsky, A;Blake, R;Heeger, DJ
通讯作者：
Heeger, DJ