Oxytocin mediates the hypothalamic action of vasoactive intestinal peptide to stimulate prolactin secretion.
Oxytocin mediates the hypothalamic action of vasoactive intestinal peptide to stimulate prolactin secretion.
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催产素介导血管活性肠肽的下丘脑作用，刺激催乳素分泌。
DOI：
10.1210/endo-124-2-812
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发表时间：
1989
期刊：
影响因子：
4.8
通讯作者：
Per Melin
中科院分区：
文献类型：
--
作者：
W. K. Samson;Rene Bianchi;Randy J. Mogg;J. Rivier;W. Vale;Per Melin
中枢给药的血管活性肠肽（VIP）刺激PRL分泌的能力，脑室内注射时，可能是由于泄漏到垂体，在那里它是已知的发挥直接的PRL释放活性，或下丘脑的行动，对自己的释放或另一种可能的PRL释放因子。将3 μ g VIP注入清醒去卵巢大鼠的第三脑室，观察到血浆催产素（OT）水平显著升高（P <0.005）和一过性升高。当去卵巢大鼠在给予3 μ g VIP前30 min静脉注射抗OT血清1 ml时，正常兔血清处理对照组注射VIP后所见的PRL峰完全消失。静脉输注生理盐水（1 ml，30 min）或在VIP注射前30 min输注VIP拮抗剂[D-4-Cl-Phe 6，Leu 17]VIP（剂量为0.5 μ g/kg.min，溶于1 ml生理盐水中）均未显著改变中心VIP给药后观察到的PRL峰。这不是由于VIP拮抗剂不能阻断VIP的PRL释放因子活性，因为在哺乳刺激范例中，它在体外和体内均显著拮抗该作用。然而，PRL激增是完全不存在的卵巢切除大鼠静脉注射OT拮抗剂，[deaminoCys 1，D-Trp 2，Val 4，Orn 8]OT，在类似的剂量。VIP对OT的这种募集表明，它可能在下丘脑-垂体轴内的多个位点起作用，以确保协调控制PRL分泌。
The ability of centrally administered vasoactive intestinal peptide (VIP) to stimulate PRL secretion when injected intracerebroventricularly could be due to leakage to the pituitary, where it is known to exert direct PRL-releasing activity, or to a hypothalamic action on its own release or that of another possible PRL-releasing factor. When 3 micrograms VIP were injected into the third ventricle of conscious ovariectomized rats, a significant (P less than 0.005) and transient elevation of plasma oxytocin (OT) levels was observed. When OVX rats were injected iv with 1 ml anti-OT serum 30 min before the central administration of 3 micrograms VIP, the PRL surge seen after VIP injection in normal rabbit serum-treated controls was completely absent. The PRL surge seen after central VIP administration was not significantly altered by iv saline infusion (1 ml over 30 min) or by infusion of a VIP antagonist [D-4-Cl-Phe6,Leu17]VIP at a dose of 0.5 microgram/kg.min in 1 ml saline for 30 min before the VIP injection. This was not due to the inability of the VIP antagonist to block the PRL-releasing factor activity of VIP, since it significantly antagonized that action both in vitro and in vivo in the suckling stimulation paradigm. However, the PRL surge was completely absent in ovariectomized rats pretreated by iv infusion of an OT antagonist, [deamino Cys1,D-Trp2,Val4,Orn8]OT, at a similar dose. This recruitment of OT by VIP indicates that it may act at more than one locus within the hypothalamo-pituitary axis to insure the coordinated control of PRL secretion.
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纳洛酮诱导催产素和催乳素释放的解离。
影响因子：
4.1
作者：
Samson,WK;McDonald,JK;Lumpkin,MD
通讯作者：
Lumpkin,MD
影响因子：
4.8
作者：
GIBBS, DM
通讯作者：
GIBBS, DM
影响因子：
4.1
作者：
Dipak K. Sarkar;Daniel Gibbs
通讯作者：
Dipak K. Sarkar;Daniel Gibbs
血管活性肠肽是大鼠催乳素释放的生理介质。
影响因子：
4.8
作者：
Abe,H;Engler,D;Molitch,ME;Bollinger-Gruber,J;Reichlin,S
通讯作者：
Reichlin,S
影响因子：
4.8
作者：
M. Lumpkin;W. Samson;S. Mccann
通讯作者：
M. Lumpkin;W. Samson;S. Mccann