Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study.
Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study.
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DOI：
10.1038/s41598-022-13740-x
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发表时间：
2022-06-23
影响因子：
4.6
通讯作者：
Akinyemiju, Tomi
中科院分区：
文献类型：
--
作者：
Gupta, Anjali;Saraiya, Veeral;Deveaux, April;Oyekunle, Taofik;Jackson, Klarissa D.;Salako, Omolola;Daramola, Adetola;Hall, Allison;Alatise, Olusegun;Ogun, Gabriel;Adeniyi, Adewale;Ayandipo, Omobolaji;Olajide, Thomas;Olasehinde, Olalekan;Arowolo, Olukayode;Adisa, Adewale;Afuwape, Oludolapo;Olusanya, Aralola;Adegoke, Aderemi;Tollefsbol, Trygve O.;Arnett, Donna;Muehlbauer, Michael J.;Newgard, Christopher B.;Akinyemiju, Tomi
关于脂质生物标志物在乳腺癌（BC）中的作用，有相互矛盾的证据，据我们所知，没有研究调查过非洲妇女之间的这种关联。我们估计了尼日利亚296例新诊断的BC病例和116名健康对照者的脂质生物标志物——总胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和甘油三酯——与BC总体和亚型（Luminal A、Luminal B、her2富集和三阴性或TNBC）的比值比（ORs）和95%置信区间（95% CI）。在完全校正模型中，甘油三酯每增加一个单位标准差（SD）， BC的患病几率增加39% （aOR: 1.39; 95% CI: 1.03, 1.86）。在绝经后妇女中，较高的总胆固醇（aOR: 1.65; 95% CI: 1.06, 2.57）、低密度脂蛋白胆固醇（aOR: 1.59; 95% CI: 1.04, 2.41）和甘油三酯（aOR: 1.91; 95% CI: 1.21, 3.01）与BC发病率增加相关。此外，LDL每增加一个单位SD， Luminal B BC的几率增加64% （aOR 1.64; 95% CI: 1.06, 2.55）。临床低HDL与TNBC风险增加2.7倍相关（aOR 2.67; 95% CI: 1.10, 6.49）。在绝经后妇女中，较高的LDL胆固醇和甘油三酯分别与Luminal B BC和HER2 BC的几率增加显著相关。总之，在非洲妇女中，低HDL和高LDL分别与TN和Luminal B BC的几率增加有关。未来的前瞻性研究可以明确地描述这种关联，并告知针对HDL的临床方法作为BC预防策略。
There is conflicting evidence on the role of lipid biomarkers in breast cancer (BC), and no study to our knowledge has examined this association among African women. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association of lipid biomarkers—total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides—with odds of BC overall and by subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC) for 296 newly diagnosed BC cases and 116 healthy controls in Nigeria. Each unit standard deviation (SD) increase in triglycerides was associated with 39% increased odds of BC in fully adjusted models (aOR: 1.39; 95% CI: 1.03, 1.86). Among post-menopausal women, higher total cholesterol (aOR: 1.65; 95% CI: 1.06, 2.57), LDL cholesterol (aOR: 1.59; 95% CI: 1.04, 2.41), and triglycerides (aOR: 1.91; 95% CI: 1.21, 3.01) were associated with increased odds of BC. Additionally, each unit SD increase in LDL was associated with 64% increased odds of Luminal B BC (aOR 1.64; 95% CI: 1.06, 2.55). Clinically low HDL was associated with 2.7 times increased odds of TNBC (aOR 2.67; 95% CI: 1.10, 6.49). Among post-menopausal women, higher LDL cholesterol and triglycerides were significantly associated with increased odds of Luminal B BC and HER2 BC, respectively. In conclusion, low HDL and high LDL are associated with increased odds of TN and Luminal B BC, respectively, among African women. Future prospective studies can definitively characterize this association and inform clinical approaches targeting HDL as a BC prevention strategy.
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影响因子：
45.3
作者：
Kitahara, Cari M.;de Gonzalez, Amy Berrington;Samet, Jonathan M.
通讯作者：
Samet, Jonathan M.
影响因子：
3.8
作者：
Akinyemiju T;Jones K;Gupta A;Oyekunle T;Saraiya V;Deveaux A;Salako O;Hall A;Alatise O;Ogun G;Adeniyi A;Ayandipo O;Olajide T;Olasehinde O;Arowolo O;Adisa A;Afuwape O;Olusanya A;Adegoke A;Tollefsbol TO;Arnett D;H3 Africa Kidney Research Network;Daramola A
通讯作者：
Daramola A
影响因子：
7.1
作者：
Chandler, Paulette D.;Song, Yiqing;Wang, Lu
通讯作者：
Wang, Lu
影响因子：
3.8
作者：
Bosco, Jaclyn L. F.;Palmer, Julie R.;Boggs, Deborah A.;Hatch, Elizabeth E.;Rosenberg, Lynn
通讯作者：
Rosenberg, Lynn
影响因子：
28.4
作者：
Global Burden of Disease Cancer Collaboration;Fitzmaurice C;Allen C;Barber RM;Barregard L;Bhutta ZA;Brenner H;Dicker DJ;Chimed-Orchir O;Dandona R;Dandona L;Fleming T;Forouzanfar MH;Hancock J;Hay RJ;Hunter-Merrill R;Huynh C;Hosgood HD;Johnson CO;Jonas JB;Khubchandani J;Kumar GA;Kutz M;Lan Q;Larson HJ;Liang X;Lim SS;Lopez AD;MacIntyre MF;Marczak L;Marquez N;Mokdad AH;Pinho C;Pourmalek F;Salomon JA;Sanabria JR;Sandar L;Sartorius B;Schwartz SM;Shackelford KA;Shibuya K;Stanaway J;Steiner C;Sun J;Takahashi K;Vollset SE;Vos T;Wagner JA;Wang H;Westerman R;Zeeb H;Zoeckler L;Abd-Allah F;Ahmed MB;Alabed S;Alam NK;Aldhahri SF;Alem G;Alemayohu MA;Ali R;Al-Raddadi R;Amare A;Amoako Y;Artaman A;Asayesh H;Atnafu N;Awasthi A;Saleem HB;Barac A;Bedi N;Bensenor I;Berhane A;Bernabé E;Betsu B;Binagwaho A;Boneya D;Campos-Nonato I;Castañeda-Orjuela C;Catalá-López F;Chiang P;Chibueze C;Chitheer A;Choi JY;Cowie B;Damtew S;das Neves J;Dey S;Dharmaratne S;Dhillon P;Ding E;Driscoll T;Ekwueme D;Endries AY;Farvid M;Farzadfar F;Fernandes J;Fischer F;G/Hiwot TT;Gebru A;Gopalani S;Hailu A;Horino M;Horita N;Husseini A;Huybrechts I;Inoue M;Islami F;Jakovljevic M;James S;Javanbakht M;Jee SH;Kasaeian A;Kedir MS;Khader YS;Khang YH;Kim D;Leigh J;Linn S;Lunevicius R;El Razek HMA;Malekzadeh R;Malta DC;Marcenes W;Markos D;Melaku YA;Meles KG;Mendoza W;Mengiste DT;Meretoja TJ;Miller TR;Mohammad KA;Mohammadi A;Mohammed S;Moradi-Lakeh M;Nagel G;Nand D;Le Nguyen Q;Nolte S;Ogbo FA;Oladimeji KE;Oren E;Pa M;Park EK;Pereira DM;Plass D;Qorbani M;Radfar A;Rafay A;Rahman M;Rana SM;Søreide K;Satpathy M;Sawhney M;Sepanlou SG;Shaikh MA;She J;Shiue I;Shore HR;Shrime MG;So S;Soneji S;Stathopoulou V;Stroumpoulis K;Sufiyan MB;Sykes BL;Tabarés-Seisdedos R;Tadese F;Tedla BA;Tessema GA;Thakur JS;Tran BX;Ukwaja KN;Uzochukwu BSC;Vlassov VV;Weiderpass E;Wubshet Terefe M;Yebyo HG;Yimam HH;Yonemoto N;Younis MZ;Yu C;Zaidi Z;Zaki MES;Zenebe ZM;Murray CJL;Naghavi M
通讯作者：
Naghavi M