Association of body composition with odds of breast cancer by molecular subtype: analysis of the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study.
Association of body composition with odds of breast cancer by molecular subtype: analysis of the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study.
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按分子亚型分类的身体成分与乳腺癌发病几率的关系：尼日利亚妇女乳腺癌既有和新危险因素的机制分析(MEND)研究。
DOI：
10.1186/s12885-021-08775-8
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发表时间：
2021-09-25
期刊：
影响因子：
3.8
通讯作者：
Daramola A
中科院分区：
文献类型：
--
作者：
Akinyemiju T;Jones K;Gupta A;Oyekunle T;Saraiya V;Deveaux A;Salako O;Hall A;Alatise O;Ogun G;Adeniyi A;Ayandipo O;Olajide T;Olasehinde O;Arowolo O;Adisa A;Afuwape O;Olusanya A;Adegoke A;Tollefsbol TO;Arnett D;H3 Africa Kidney Research Network;Daramola A
在美国、欧洲和亚洲的研究人群中，肥胖和乳腺癌(BC)之间的联系已经得到了广泛的研究，但证据往往相互矛盾。然而，尽管肥胖和相关疾病在非洲日益普遍，非洲是全球年龄标准化BC死亡率最高的大陆，但很少有研究评估这种联系，也没有研究非洲妇女的分子亚型。目前的分析调查了非洲女性的身体成分(由体重指数(BMI)、身高和体重定义)与BC(由分子亚型定义)之间的联系。我们在419例组织学确诊的BC病例和286例健康对照中，从已确定的和新的尼日利亚裔妇女乳腺癌危险因素的机制(MEND)病例对照研究中，估计了身体成分和BC的测量与分子亚型之间的关联的优势比(OR)和95%可信区间(95%CI)。在调整后的模型中，较高的BMI(AOR：0.79；95%CI：0.67，0.95)和体重(AOR：0.83；95%CI：0.69，0.98)与BC的风险降低相关，而身高与BC的风险增加无统计学意义(AOR：1.07，95%CI：0.90，1.28)。在绝经前/围绝经期妇女中，而不是绝经后妇女中，较高的BMI和体重都与BC的发生几率显著相关。此外，较高的BMI与绝经前/围绝经期妇女发生腔A、腔B和HER2富集型BC的几率降低，以及绝经后妇女患三重阴性BC的几率降低相关。较高的BMI和体重与西非女性总体和分子亚型患BC的几率降低有关。需要对非洲裔妇女进行更大规模的研究，以明确这些联系的特征，并为癌症预防战略提供信息。
The association between obesity and breast cancer (BC) has been extensively studied among US, European and Asian study populations, with often conflicting evidence. However, despite the increasing prevalence of obesity and associated conditions in Africa, the continent with the highest age-standardized BC mortality rate globally, few studies have evaluated this association, and none has examined in relation to molecular subtypes among African women. The current analysis examines the association between body composition, defined by body mass index (BMI), height, and weight, and BC by molecular subtype among African women. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for the association between measures of body composition and BC and molecular subtypes among 419 histologically confirmed cases of BC and 286 healthy controls from the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Women of Nigerian Descent (MEND) case-control study. Higher BMI (aOR: 0.79; 95% CI: 0.67, 0.95) and weight (aOR: 0.83; 95% CI: 0.69, 0.98) were associated with reduced odds of BC in adjusted models, while height was associated with non-statistically significant increased odds of BC (aOR: 1.07, 95% CI: 0.90, 1.28). In pre/peri-menopausal, but not post-menopausal women, both higher BMI and weight were significantly associated with reduced odds of BC. Further, higher BMI was associated with reduced odds of Luminal A, Luminal B, and HER2-enriched BC among pre/peri-menopausal women, and reduced odds of triple-negative BC among post-menopausal women. Higher BMI and weight were associated with reduced odds of BC overall and by molecular subtype among West African women. Larger studies of women of African descent are needed to definitively characterize these associations and inform cancer prevention strategies.
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代谢综合征以及种族，更年期和BMI的乳腺癌和亚型的风险。
影响因子：
5.2
作者：
Dibaba DT;Braithwaite D;Akinyemiju T
通讯作者：
Akinyemiju T
影响因子：
3.8
作者：
Agresti, Roberto;Meneghini, Elisabetta;Sant, Milena
通讯作者：
Sant, Milena
影响因子：
4.6
作者：
His, Mathilde;Biessy, Carine;Rinaldi, Sabina
通讯作者：
Rinaldi, Sabina
DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
影响因子：
2.3
作者：
Ogundiran, Temidayo O.;Huo, Dezheng;Adenipekun, Adeniyi;Campbell, Oladapo;Oyesegun, Rasaaq;Akang, Effiong;Adebamowo, Clement;Olopade, Olufunmilayo I.
通讯作者：
Olopade, Olufunmilayo I.