Cryptococcus gattii: a resurgent fungal pathogen.

Cryptococcus gattii: a resurgent fungal pathogen.
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DOI:
10.1016/j.tim.2011.07.010
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发表时间:
2011-11
影响因子:
15.9
通讯作者:
Chaturvedi, Sudha
Chaturvedi, Sudha
中科院分区:
生物学1区
文献类型:
--
作者:
Chaturvedi, Vishnu;Chaturvedi, Sudha

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格特隐球菌和新型隐球菌是隐球菌病的病原体,隐球菌病表现为肺炎和脑膜炎。最近,由于不列颠哥伦比亚省、加拿大和美国太平洋西北地区的爆发,格特隐球菌受到了广泛关注。这种树栖酵母的生物学相对尚未被探索,并且关于它如何引起人类和动物感染的线索很少。在这篇综述中,我们总结了有关格特隐球菌遗传学及其生态位的最新发现,并重点介绍了未来探索的成熟领域。对流行病学、生态模型和宿主与病原体相互作用的更多关注预计将有助于更好地了解这种神秘的酵母菌,并最终制定出更好的控制措施。
Cryptococcus gattii and C. neoformans are causal agents of cryptococcosis, which manifests as pneumonia and meningitis. C. gattii has recently received widespread attention due to outbreaks in British Columbia, Canada and the US Pacific Northwest. The biology of this tree-dwelling yeast is relatively unexplored, and there are few clues about how it causes infections in humans and animals. In this review, we summarize recent discoveries about C. gattii genetics and its ecological niche and highlight areas ripe for future exploration. Increased focus on epidemiology, ecological modeling, and host-pathogen interactions is expected to yield a better understanding of this enigmatic yeast, and ultimately lead to better measures for its control.
DOI: 10.1128/iai.63.7.2632-2644.1995
发表时间: 1995-07-01
影响因子: 3.1
作者:
DONG, ZM;MURPHY, JW
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