Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions.
Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions.
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DOI：
10.3390/microorganisms9020353
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发表时间：
2021-02-11
期刊：
影响因子：
4.5
通讯作者：
Callewaert C
中科院分区：
文献类型：
--
作者：
De Pessemier B;Grine L;Debaere M;Maes A;Paetzold B;Callewaert C
微生物群在多种皮肤病中起着重要作用。不仅皮肤微生物群发生了变化，而且令人惊讶的是，许多皮肤病都伴随着肠道微生物群的变化。微生物组是免疫系统的关键调节器，因为它的目标是通过与组织和器官双向通信来维持动态平衡。因此，皮肤和/或肠道微生物群的失调与免疫反应的改变有关，从而促进皮肤病的发展，如特应性皮炎、牛皮癣、寻常痤疮、头皮屑，甚至皮肤癌。在这里，我们集中讨论微生物群、饮食、代谢产物和皮肤病理中的免疫反应之间的关系。本文详细介绍了常见皮肤疾病与皮肤微生物群失调的关系，以及目前有关肠道微生物群失调、饮食联系及其与皮肤疾病的相互作用的大量证据。有必要加强对局部皮肤和肠道微生物群的了解，包括潜在的机制，以阐明微生物参与人类皮肤病并开发新的治疗方法。
The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. Hence, dysbiosis in the skin and/or gut microbiome is associated with an altered immune response, promoting the development of skin diseases, such as atopic dermatitis, psoriasis, acne vulgaris, dandruff, and even skin cancer. Here, we focus on the associations between the microbiome, diet, metabolites, and immune responses in skin pathologies. This review describes an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiosis, dietary links, and their interplay with skin conditions. An enhanced understanding of the local skin and gut microbiome including the underlying mechanisms is necessary to shed light on the microbial involvement in human skin diseases and to develop new therapeutic approaches.
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影响因子：
14.2
作者：
Assan, Florence;Gottlieb, Jeremy;Bachelez, Herve
通讯作者：
Bachelez, Herve
影响因子：
5.2
作者：
Bosman, Else S.;Albert, Arianne Y.;Vallance, Bruce A.
通讯作者：
Vallance, Bruce A.
影响因子：
4.6
作者：
Andersson, Tilde;Bergdahl, Gizem Erturk;Lood, Rolf
通讯作者：
Lood, Rolf
影响因子：
24.5
作者：
BARRY, RE;SALMON, PR;WARIN, RP
通讯作者：
WARIN, RP
DOI：
10.13188/2373-1044.1000019
发表时间：
2015-12
期刊：
Journal of clinical and investigative dermatology
影响因子：
--
作者：
Borda LJ;Wikramanayake TC
通讯作者：
Wikramanayake TC