Antibiotics-Free Compounds for Chronic Wound Healing.
Antibiotics-Free Compounds for Chronic Wound Healing.
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DOI：
10.3390/pharmaceutics14051021
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发表时间：
2022-05-09
期刊：
影响因子：
5.4
通讯作者：
Liu, Lian X.
中科院分区：
文献类型：
--
作者：
Oluwole, David O.;Coleman, Lucy;Buchanan, William;Chen, Tao;La Ragione, Roberto M.;Liu, Lian X.
与慢性伤口相关的健康负担的迅速增加引起了政策制定者、学术界和工业界的极大关注。这可能是由于这种情况的破坏性影响，特别是慢性伤口与影响患者生活质量的侵入性微生物感染有关。不幸的是，由于抗生素对细菌生物膜的渗透性差以及抗菌素耐药性的出现，抗生素并不总是有用的。因此，迫切需要探索具有已证实或潜在的抗菌、抗炎、抗氧化和伤口愈合功效的无抗生素化合物/配方。无抗生素化合物的机制被认为包括破坏细菌细胞结构，阻止细胞分裂，膜孔，运动性和生物膜的形成。此外，这些化合物中的一些通过调节生长因子的表达来促进组织再生。在这篇综述文章中，重点是放在一些非抗生素化合物具有一些上述药理和生理活性。特别关注芦荟、姜黄素、肉桂醛、聚己胺、类维生素a、抗坏血酸、生育酚和壳聚糖。这些化合物（当单独使用或与其他生物活性分子联合使用时）可能是治疗或预防慢性伤口的可靠选择。
The rapid rise in the health burden associated with chronic wounds is of great concern to policymakers, academia, and industry. This could be attributed to the devastating implications of this condition, and specifically, chronic wounds which have been linked to invasive microbial infections affecting patients’ quality of life. Unfortunately, antibiotics are not always helpful due to their poor penetration of bacterial biofilms and the emergence of antimicrobial resistance. Hence, there is an urgent need to explore antibiotics-free compounds/formulations with proven or potential antimicrobial, anti-inflammatory, antioxidant, and wound healing efficacy. The mechanism of antibiotics-free compounds is thought to include the disruption of the bacteria cell structure, preventing cell division, membrane porins, motility, and the formation of a biofilm. Furthermore, some of these compounds foster tissue regeneration by modulating growth factor expression. In this review article, the focus is placed on a number of non-antibiotic compounds possessing some of the aforementioned pharmacological and physiological activities. Specific interest is given to Aloe vera, curcumin, cinnamaldehyde, polyhexanide, retinoids, ascorbate, tocochromanols, and chitosan. These compounds (when alone or in formulation with other biologically active molecules) could be a dependable alternative in the management or prevention of chronic wounds.
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影响因子：
3.4
作者：
Baldrick, Paul
通讯作者：
Baldrick, Paul
影响因子：
5.8
作者：
Anand, Preetha;Nair, Hareesh B.;Sung, Bokyung;Kunnumakkara, Ajaikumar B.;Yadav, Vivek R.;Tekmal, Rajeshwar R.;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.
影响因子：
6.5
作者：
Antille, C;Tran, C;Saurat, JH
通讯作者：
Saurat, JH
DOI：
10.7241/ourd.20174.108
发表时间：
2017-01-01
期刊：
Our Dermatology Online
影响因子：
--
作者：
Bijo Elsy, Bijo Elsy;Khan, A. A.;Maheshwari, V.
通讯作者：
Maheshwari, V.
影响因子：
1.9
作者：
Alblas, J. G.;Andriessen, A.;van Gent, M.
通讯作者：
van Gent, M.