Does overnight duty affect vascular endothelial function?
Does overnight duty affect vascular endothelial function?
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DOI：
10.1186/s12872-021-02277-y
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发表时间：
2021-09-27
影响因子：
2.1
通讯作者：
Yano S
中科院分区：
文献类型：
--
作者：
Garu A;Nitta E;Yoshida Y;Yata E;Tsunematsu A;Araki T;Nagai A;Yano S
反应性充血指数（RHI）是通过外周动脉张力测定（PAT）获得的，与反应性充血时舒张末期动脉直径的百分比变化（%流量介导的扩张）高度相关。据报告，低RHI是心血管（CV）疾病高风险患者的死亡风险。心血管事件被认为是由身体和精神压力引起的，包括长期疲劳和睡眠不足。然而，疲劳，睡眠不足和内皮功能之间的关系尚未建立。平均年龄为31.6岁的健康医院工作人员（n = 13，6名男性和7名女性）在提供书面知情同意书后被分配至本研究。在研究期间，我们进行了72测量反应性充血外周动脉张力（RH-PAT）在早晨之前或之后的职责。在每次测量RH-PAT时，我们记录了参与者的睡眠时间，并使用视觉模拟量表（VAS）评估了他们的疲劳程度。尽管VAS显著低于（36 ± 16%和64 ± 12%，P < 0.001），睡眠时间较长执勤前（6.0 ± 1.1小时和2.3 ± 1.0小时，p < 0.001）与执勤后相比，两者的RHI相当（2.12 ± 0.53 vs. 1.97 ± 0.50，p = 0.21）。低RHI参与者（< 1.67）的VAS评分显著高于正常RHI参与者（≥ 2.07）（分别为59 ± 13%和46 ± 21%，p < 0.05）。然而，二元逻辑回归显示，当调整全身血压（SBP）和心率变异性（HRV）时，低RHI和VAS之间无显著相关性。在简单回归分析中，RHI与VAS评分显著相关，但与睡眠时间无关。多元线性回归分析也显示，调整SBP和HRV后，RHI和VAS评分之间无显著相关性。在健康的年轻人中，血管内皮功能与夜间值班、睡眠时间或疲劳程度无关。由于在严重疲劳条件下，RHI可能会通过自主神经活动而降低，因此在评估RH-PAT结果时应考虑受试者的身体和精神状况。在线版本包含补充材料，可通过10.1186/s12872-021-02277-y获得。
The reactive hyperemia index (RHI), which is obtained from the measurement of peripheral arterial tonometry (PAT), is highly associated with the percentage change in the end-diastolic arterial diameter (%flow-mediated dilatation) at reactive hyperemia. Low RHI is reported to be a mortality risk in patients with a high risk of cardiovascular (CV) disease. CV events are thought to be induced by physical and mental stress, including long-term fatigue and lack of sleep. However, the relationship between fatigue, lack of sleep, and endothelial function has not yet been established. Healthy hospital workers (n = 13, 6 men and 7 women) with an average age of 31.6 years were assigned to this study after they provided written informed consent. During the study period, we conducted 72 measurements of reactive hyperemia-peripheral arterial tonometry (RH-PAT) in the morning before or after their duty. At each measurement of the RH-PAT, we recorded the participants’ hours of sleep and evaluated their degree of fatigue using a visual analog scale (VAS). Although the VAS was significantly less (36 ± 16% and 64 ± 12%, p < 0.001) and the hours of sleep were longer (6.0 ± 1.1 h and 2.3 ± 1.0 h, p < 0.001) before duty compared to those after duty, the RHI was comparable between them (2.12 ± 0.53 vs. 1.97 ± 0.50, p = 0.21). The VAS score was significantly higher in participants with low RHI (< 1.67) than in those with normal RHI (≥ 2.07) (59 ± 13% and 46 ± 21%, respectively, p < 0.05). However, binary logistic regression showed no significant association between low RHI and the VAS when adjusted for systemic blood pressure (SBP) and heart rate variability (HRV). In a simple regression analysis, the RHI was significantly correlated with the VAS score but not with sleep duration. A multiple linear regression analysis also showed no significant association between the RHI and VAS scores after adjustment for SBP and HRV. Vascular endothelial function was not associated with overnight duty, hours of sleep, or degree of fatigue in healthy young adults. Since the RHI may be decreased in severe fatigue conditions through autonomic nerve activity, one should consider the physical and mental conditions of the examinee when evaluating the RH-PAT results. The online version contains supplementary material available at 10.1186/s12872-021-02277-y.
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影响因子：
9.1
作者：
Mullington, Janet M.;Haack, Monika;Toth, Maria;Serrador, Jorge A.;Meier-Ewert, Hans K.
通讯作者：
Meier-Ewert, Hans K.
影响因子：
3
作者：
Alboni, Paolo;Favaron, Elisa;Pedaci, Mario
通讯作者：
Pedaci, Mario
影响因子：
5.6
作者：
Carlson, Scott H.;Wyss, J. Michael
通讯作者：
Wyss, J. Michael
影响因子：
3.4
作者：
Ketterer, Mark W.;Keteyian, S. J.;Deveshwar, S.
通讯作者：
Deveshwar, S.
影响因子：
37.8
作者：
Benjamin, EJ;Larson, MG;Vita, JA
通讯作者：
Vita, JA