Mapping the face in the somatosensory brainstem.

Mapping the face in the somatosensory brainstem.
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DOI:
10.1038/nrn2804
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发表时间:
2010-04
影响因子:
34.7
通讯作者:
Rijli, Filippo M.
Rijli, Filippo M.
中科院分区:
医学1区
文献类型:
--
作者:
Erzurumlu, Reha S.;Murakami, Yasunori;Rijli, Filippo M.

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大脑皮质中的面部体感图谱来自于面部表征,这些表征首先在脑干水平建立,然后在躯体感觉通路的每个阶段被连续复制。最近的研究为小鼠脑干三叉神经核团中面部和胡须的体视定位图的发展提供了分子机制的见解。这项工作揭示了三叉神经节和脑干靶神经元的早期分子区域化和定位模式是由同源结构域转录因子建立的,其表达受来自大脑和面部的信号的诱导和维持。这种与位置相关的信息是将感觉感受器的早期空间布局转换为授予更高大脑水平的地形图的基础。
The facial somatosensory map in the cortex is derived from facial representations that are first established at the brainstem level and then serially ‘copied’ at each stage of the somatosensory pathway. Recent studies have provided insights into the molecular mechanisms involved in the development of somatotopic maps of the face and whiskers in the trigeminal nuclei of the mouse brainstem. This work has revealed that early molecular regionalization and positional patterning of trigeminal ganglion and brainstem target neurons are established by homeodomain transcription factors, the expression of which is induced and maintained by signals from the brain and face. Such position-dependent information is fundamental in transforming the early spatial layout of sensory receptors into a topographic connectivity map that is conferred to higher brain levels.
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