Effects of oral administration of yoghurt whey on free amino acid concentration in rat brains
Effects of oral administration of yoghurt whey on free amino acid concentration in rat brains
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口服酸奶乳清对大鼠脑游离氨基酸浓度的影响
DOI：
10.11266/jpan.22.2_84
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
M.
中科院分区：
文献类型：
--
作者：
Kawase;T. and Furuse;M.
酸奶是最广泛消费的传统乳制品之一，使用细菌发酵，具有生理益处，因为它包含许多营养素，如维生素，氨基酸，肽，蛋白质和脂质。此外，由于发酵，酸奶中的乳糖含量低于牛奶，因此哺乳动物腹泻的风险降低。乳清是酸奶，奶酪和黄油制作的副产品，我们建议酸奶乳清可以用作伴侣动物以及人类和家畜的食品成分。为了评估酸奶乳清的功能，在本研究中，我们调查了是否口服由德氏乳杆菌亚种产生的酸奶乳清。保加利亚链球菌2038和嗜热链球菌1131影响大鼠脑中游离氨基酸的浓度和行为。我们通过旷场试验评估运动活动、焦虑样行为和学习能力，通过强迫游泳试验评估抑郁样行为。我们还确定了D-和L-氨基酸的浓度在血浆和脑区的超高效液相色谱法。酸奶乳清和蒸馏水（对照）治疗之间没有显着的影响，注意到在所有参数的行为测试。然而，D-和L-Ser，L-Gln，L-His，L-Ala，L-Arg，L-Phe，L-Val，L-Leu，L-Ile，和Tau在丘脑和L-Gln在脑干中降低，和GABA在下丘脑中增加酸奶乳清处理。总之，口服酸奶乳清改变了大鼠特定脑区的几种氨基酸浓度，但从行为测试来看并不影响精神状况。
Yoghurt, one of the most widely consumed traditional dairy products, uses bacterial fermentation and has physiological benefits as it includes many nutrients such as vitamins, amino acids, peptides, proteins, and lipids. Moreover, because the amount of lactose is lower in yoghurt than in milk due to the fermentation, the risk of diarrhea in mammals is reduced. Whey is a byproduct of yoghurt, cheese, and butter making, and we propose that yoghurt whey could be used as a food ingredient for companion animals as well as for human and domestic animals. To assess the functions of yoghurt whey in the present study, we investigated whether the oral administration of yoghurt whey produced by Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 affected the concentrations of free amino acids in the brain and behavior in rats. We evaluated motor activity, anxiety-like behavior, and learning ability by the open field test and depression-like behavior by the forced swimming test. We also determined the concentrations of D-and L-amino acids in the plasma and brain regions by ultra-performance liquid chromatography. No significant effects were noted between yoghurt whey and distilled water (control) treatments in all parameters of behavioral tests. However, D-and L-Ser, L-Gln, L-His, L-Ala, L-Arg, L-Phe, L-Val, L-Leu, L-Ile, and Tau in the thalamus and L-Gln in the brainstem were lowered, and GABA in the hypothalamus was increased by yoghurt whey treatment. In conclusion, the oral administration of yoghurt whey altered several amino acid concentrations in specific brain regions of rats, but did not affect the mental conditions judging from behavioral tests.
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影响因子：
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作者：
C. Yilmaz;V. Gökmen
通讯作者：
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影响因子：
3.4
作者：
Sawai, H;Hannun, YA
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影响因子：
29.4
作者：
Tillisch K;Labus J;Kilpatrick L;Jiang Z;Stains J;Ebrat B;Guyonnet D;Legrain-Raspaud S;Trotin B;Naliboff B;Mayer EA
通讯作者：
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影响因子：
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作者：
Formigoni, A.;Piva, A.;Biagi, G.
通讯作者：
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长期服用酸奶可改善小鼠的空间记忆
DOI：
--
发表时间：
2019
期刊：
影响因子：
--
作者：
Takahiro Kawase;M. Furuse
通讯作者：
M. Furuse