Circulating polyunsaturated fatty acids, pressure pain thresholds, and nociplastic pain conditions.
Circulating polyunsaturated fatty acids, pressure pain thresholds, and nociplastic pain conditions.
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DOI：
10.1016/j.plefa.2022.102476
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发表时间：
2022-09
影响因子：
3
通讯作者：
Slade, Gary D.
中科院分区：
文献类型：
--
作者：
Sanders, Anne E.;Weatherspoon, Diane;Ehrmann, Brandie M.;Soma, Paul S.;Shaikh, Saame R.;Preisser, John S.;Ohrbach, Richard;Fillingim, Roger B.;Slade, Gary D.
关键词：
多不饱和脂肪酸（PUFA）在疼痛调节中起作用。这项研究试图确定红细胞中发现的游离PUFA是否也在伤害性处理中发挥作用。我们研究了循环PUFAs和伤害性机械刺激的伤害性阈值之间的关联。我们还确定了伤害性阈值是否与伤害性疼痛条件有关。这项横断面研究使用了储存的红细胞和来自OPPERA-2慢性重叠疼痛状况研究中605名成年参与者的数据。在OPPERA-2成人完成定量感觉测试，其中压力痛觉测量法测量了6个解剖部位的深部肌肉组织敏感性。标准化的协议分类成人存在或不存在五个伤害性疼痛条件：颞下颌关节紊乱病，头痛，腰痛，肠易激综合征和纤维肌痛。液相色谱串联质谱定量红细胞PUFA。我们进行了三组分析。首先，多变量线性回归模型评估了n-6/n-3 PUFA比率与重叠伤害性疼痛状况数量之间的相关性。第二，一系列的36个多变量线性回归模型评估协变量调整PUFA和伤害性阈值之间的关联，在每个六个解剖部位。第三，一系列的30个多变量线性回归模型评估协变量调整的伤害性阈值之间的关联，在六个解剖部位和五个疼痛条件。在多元线性回归中，n-6/n-3 PUFA比值每增加一个单位，疼痛状况就更多（β = 0.30，95%置信限：0.07，0.53，p = 0.012）。ω-6亚油酸和花生四烯酸分别在三个和五个解剖部位与较低的伤害性阈值呈负相关。相比之下，ω-3 α-亚麻酸，二十碳五烯酸，二十二碳六烯酸和n-6/n-3 PUFA比例与任何部位的伤害性阈值无关。疼痛病例在所有解剖部位的伤害性阈值均显著低于非病例对照组。较高的n-6/n-3 PUFA比率与更多的疼痛状况相关。Omega-6 PUFA可能促进伤害性处理的普遍上调。
Polyunsaturated fatty acids (PUFAs) play a role in pain regulation. This study sought to determine whether free PUFAs found in red blood cells also play a role in nociceptive processing. We examined associations between circulating PUFAs and nociceptive thresholds to noxious mechanical stimuli. We also determined whether nociceptive thresholds were associated with nociplastic pain conditions. This cross-sectional study used stored red bloods cells and data from 605 adult participants in the OPPERA-2 study of chronic overlapping pain conditions. In OPPERA-2 adults completed quantitative sensory testing in which pressure algometry measured deep muscular tissue sensitivity at six anatomical sites. Standardized protocols classified adults for presence or absence of five nociplastic pain conditions: temporomandibular disorder, headache, low back pain, irritable bowel syndrome and fibromyalgia. Liquid chromatography tandem mass spectroscopy quantified erythrocyte PUFAs. We conducted three sets of analyses. First, a multivariable linear regression model assessed the association between n-6/n-3 PUFA ratio and the number of overlapping nociplastic pain conditions. Second, a series of 36 multivariable linear regression models assessed covariate-adjusted associations between PUFAs and nociceptive thresholds at each of six anatomical sites. Third, a series of 30 multivariable linear regression models assessed covariate-adjusted associations between nociceptive thresholds at six anatomical sites and each of five pain conditions. In multiple linear regression, each unit increase in n-6/n-3 PUFA ratio was associated with more pain conditions (β = 0.30, 95% confidence limits: 0.07, 0.53, p = 0.012). Omega-6 linoleic acid and arachidonic acid were negatively associated with lower nociceptive thresholds at three and at five, respectively, anatomical sites. In contrast, omega-3 alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid and the n-6/n-3 PUFA ratio were not associated with nociceptive thresholds at any site. Pain cases had significantly lower nociceptive thresholds than non-case controls at all anatomical sites. A higher n-6/n-3 PUFA ratio was associated with more pain conditions. Omega-6 PUFAs may promote a generalized upregulation of nociceptive processing.
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影响因子：
7.4
作者：
Lautenbacher, S;Kunz, M;Arendt-Nielsen, L
通讯作者：
Arendt-Nielsen, L
影响因子：
7.1
作者：
BJERVE, KS;BRUBAKK, AM;VIK, T
通讯作者：
VIK, T
影响因子：
7.4
作者：
Domenichiello AF;Jensen JR;Zamora D;Horowitz M;Yuan ZX;Faurot K;Mann JD;Mannes AJ;Ramsden CE
通讯作者：
Ramsden CE
影响因子：
7.4
作者：
Goldberg, Robert J.;Katz, Joel
通讯作者：
Katz, Joel
影响因子：
4
作者：
Bair, Eric;Brownstein, Naomi C.;Slade, Gary D.
通讯作者：
Slade, Gary D.