The longevity of memory CD8 T cell responses after repetitive antigen stimulations.
The longevity of memory CD8 T cell responses after repetitive antigen stimulations.
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DOI：
10.4049/jimmunol.1301063
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发表时间：
2014-06-15
期刊：
影响因子：
--
通讯作者：
Badovinac VP
中科院分区：
文献类型：
--
作者：
Rai D;Martin MD;Badovinac VP
In experimental models where the antigen (Ag) stimulation history of memory CD8 T cell populations was clearly defined (adoptive transfer of a known number of T-cell-receptor transgenic memory CD8 T cells) all facets of the ensuing CD8 T cell responses including proliferative expansion, duration and extent of contraction, diversification of memory CD8 T cell transcriptomes, and life-long survival were dependent on the number of prior Ag-encounters. However, the extent to which sequential adoptive transfers models reflect the physiological scenario in which memory CD8 T cells are generated by repetitive Ag-challenges of individual hosts (no adoptive transfer involved) are not known. Direct comparison of endogenous memory CD8 T cell responses generated in repetitively infected hosts revealed that recurrent homologous boosting was required to preserve the numbers and increase the phenotypic and functional complexity of the developing memory CD8 T cell pool. Although life-long survival of the memory CD8 T cells was not impacted, phenotype (i.e. upregulation of CD62L) and function (i.e. homeostatic turnover, Ag-stimulated IL-2 production) of repeatedly stimulated memory CD8 T cells was dependent on time after last Ag-encounter. Therefore, repetitive Ag-challenges of individual hosts can substantially influence the numerical and functional attributes of polyclonal memory CD8 T cells, a notion with important implications for the design of future vaccination strategies aimed at increasing the number of protective memory CD8 T cells.
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DOI：
10.1084/jem.20052237
发表时间：
2006-04-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jabbari A;Harty JT
通讯作者：
Harty JT
影响因子：
32.4
作者：
Fraser KA;Schenkel JM;Jameson SC;Vezys V;Masopust D
通讯作者：
Masopust D
影响因子：
30.5
作者：
Kaech, SM;Tan, JT;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
82.9
作者：
Badovinac, VP;Messingham, KAN;Harty, JT
通讯作者：
Harty, JT
影响因子：
4.4
作者：
Masopust, David;Ha, Sang-Jun;Ahmed, Rafi
通讯作者：
Ahmed, Rafi