Glutamate dysfunction associated with developmental cerebellar damage: relevance to autism spectrum disorders.
Glutamate dysfunction associated with developmental cerebellar damage: relevance to autism spectrum disorders.
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DOI：
10.1007/s12311-013-0541-4
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发表时间：
2014-06
期刊：
影响因子：
3.5
通讯作者：
Mittleman, Guy
中科院分区：
文献类型：
--
作者：
McKimm, Eric;Corkill, Beau;Goldowitz, Dan;Albritton, Lorraine M.;Homayouni, Ramin;Blaha, Charles D.;Mittleman, Guy
Neural abnormalities commonly associated with autism spectrum disorders include prefrontal cortex (PFC) dysfunction and cerebellar pathology in the form of Purkinje cell loss and cerebellar hypoplasia. It has been reported that loss of cerebellar Purkinje cells results in aberrant dopamine neurotransmission in the PFC which occurs via dysregulation of multisynaptic efferents from the cerebellum to the PFC. Using a mouse model we investigated the possibility that developmental cerebellar Purkinje cell loss could disrupt glutamatergic cerebellar projections to the PFC that ultimately modulate DA release. We measured glutamate release evoked by local electrical stimulation using fixed potential amperometry in combination with glutamate selective enzyme-based recording probes in urethane anesthetized Lurcher mutant and wildtype mice. Target sites included the medio-dorsal and ventro-lateral thalamic nuclei, reticulo-tegmental nuclei, pedunculopontine nuclei, and ventral tegmental area. With the exception of the ventral tegmental area, results indicated that in comparison to wildtype mice, evoked glutamate release was reduced in Lurcher mutants by between 9% to 72% at all stimulated sites. These results are consistent with the notion that developmental loss of cerebellar Purkinje cells drives reductions in evoked glutamate release in cerebellar efferent pathways that ultimately influence PFC dopamine release. Possible mechanisms whereby reductions in glutamate release could occur are discussed.
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影响因子：
--
作者：
Middleton, FA;Strick, PL
通讯作者：
Strick, PL
DOI：
10.1111/j.1460-9568.2009.07073.x
发表时间：
2010-02
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Martin LA;Goldowitz D;Mittleman G
通讯作者：
Mittleman G
影响因子：
158.5
作者：
COURCHESNE, E;YEUNGCOURCHESNE, R;JERNIGAN, TL
通讯作者：
JERNIGAN, TL
影响因子：
2.7
作者：
Chudasama, Y;Passetti, F;Robbins, TW
通讯作者：
Robbins, TW
DOI：
10.1098/rstb.1979.0055
发表时间：
1979-01-01
影响因子：
6.3
作者：
CADDY, KWT;BISCOE, TJ
通讯作者：
BISCOE, TJ