Challenges in quantifying food intake in rodents.

Challenges in quantifying food intake in rodents.
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DOI:
10.1016/j.brainres.2018.02.040
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发表时间:
2018-08-15
期刊:
影响因子:
2.9
通讯作者:
Kravitz AV
Kravitz AV
中科院分区:
医学3区
文献类型:
--
作者:
Ali MA;Kravitz AV

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进食是动物赖以生存的关键行为,摄食的病理变化是肥胖和神经性厌食症等疾病的基础。为了了解这些疾病及其在动物模型中的发展,研究人员必须量化食物摄入量。尽管概念上很简单,但获取啮齿动物食物摄入量的准确记录仍然是一个挑战。人们使用了几种方法来实现这一点,每一种方法都有其优点和缺点。在这篇文章中,我们调查了四种最常见的测量啮齿动物食物摄入量的方法:手动称量食物、自动称重秤、颗粒分配器和基于视频的分析。我们强调了每种方法在喂养研究中使用的优点和缺点,重点是准确性、潜在的误差来源、可负担性以及与其使用相关的实际问题。最后,我们讨论了喂养装置的前景和测量实验室啮齿动物食物摄入量的未解决的挑战。
Feeding is a critical behavior that animals depend on for survival, and pathological alterations in food intake underlie disorders such as obesity and anorexia nervosa. To understand these disorders and their development in animal models, researchers must quantify food intake. Although conceptually straightforward, it remains a challenge to obtain accurate records of food intake in rodents. Several approaches have been used to accomplish this, each with benefits and drawbacks. In this article, we survey the four most common methods for measuring food intake in rodents: manual weighing of food, automated weighing scales, pellet dispensers, and video-based analyses. We highlight each method's benefits and drawbacks for use in feeding research, focusing on accuracy, potential sources of errors, affordability, and practical concerns relating to their use. Finally, we discuss the outlook for feeding devices and unmet challenges for measuring food intake in laboratory rodents.
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