Ytterbium Nanoparticle Contrast Agents for Conventional and Spectral Photon-Counting CT and Their Applications for Hydrogel Imaging.
Ytterbium Nanoparticle Contrast Agents for Conventional and Spectral Photon-Counting CT and Their Applications for Hydrogel Imaging.
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DOI：
10.1021/acsami.2c12354
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发表时间：
2022-08-31
影响因子：
9.5
通讯作者：
Cormode, David P.
中科院分区：
文献类型：
--
作者：
Dong, Yuxi C.;Kumar, Ananyaa;Rosario-Berrios, Derick N.;Si-Mohamed, Salim;Hsu, Jessica C.;Nieves, Lenitza M.;Douek, Philippe;Noel, Peter B.;Cormode, David P.
为了开发用于计算机断层扫描(CT)的纳米颗粒造影剂，人们已经做了大量的工作，重点是确定更安全和更有效的配方。光谱光子计数计算机断层扫描(SPCCT)造影剂是一种源于传统CT的快速发展的成像方式，最近也得到了相当大的关注。在这项研究中，我们探索了超微纳米YbNP的合成，并证明了它们可能被用作常规CT和SPCCT造影剂。这些纳米粒子在体外用各种成像系统测试了它们的细胞毒性和对比剂生成特性。当用常规CT和SPCCT在临床相关能量下扫描时，YbNP的衰减程度明显高于研究最充分的金纳米颗粒(AuNP)。此外，还研究了YbNP在水凝胶标记和监测方面的潜在应用。水凝胶中YbNP有效载荷的存在使得水凝胶能够在体内定位和跟踪。此外，体内成像结果显示，与用作标记的AuNP相比，YbNP产生了更高的对比度。总之，这是第一次将超小YbNP作为常规CT和SPCCT造影剂，并将它们用于水凝胶系统以使其不受辐射影响的研究。这些发现强调了YbNP作为CT和SPCCT造影剂的用途，以及它们在体内追踪水凝胶的潜力。
Significant work has been done to develop nanoparticle contrast agents for computed tomography (CT), with a focus on identifying safer and more effective formulations. Contrast agents for spectral photon-counting computed tomography (SPCCT), a fast-growing imaging modality derived from conventional CT, have also recently gained considerable attention. In this study, we explored the synthesis of ultrasmall ytterbium nanoparticles (YbNP) and demonstrated that, potentially, they can be used as conventional CT and SPCCT contrast agents. These nanoparticles were tested in vitro for their cytotoxicity and contrast-generating properties with a variety of imaging systems. When scanned with conventional CT and SPCCT at clinically relevant energies, YbNP are significantly more attenuating than gold nanoparticles (AuNP), the contrast agents that have been most well studied. Furthermore, YbNP were studied for their potential application for labeling and monitoring hydrogels. The presence of the YbNP payload in hydrogels allowed for hydrogel localization and tracking in vivo. Additionally, the in vivo imaging results revealed that YbNP generate higher contrast when compared to AuNP used as a label. In summary, this is the first research study to examine ultrasmall YbNP as conventional CT and SPCCT contrast agents, as well as using them in a hydrogel system to make it radiopaque. These findings underscore YbNP’s utility as CT and SPCCT contrast agents, as well as their potential for tracking hydrogels in vivo.
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影响因子：
4.6
作者：
Kopp, Felix K.;Daerr, Heiner;Noel, Peter B.
通讯作者：
Noel, Peter B.
影响因子：
4.6
作者：
Cormode DP;Si-Mohamed S;Bar-Ness D;Sigovan M;Naha PC;Balegamire J;Lavenne F;Coulon P;Roessl E;Bartels M;Rokni M;Blevis I;Boussel L;Douek P
通讯作者：
Douek P
影响因子：
4.6
作者：
Kim J;Bar-Ness D;Si-Mohamed S;Coulon P;Blevis I;Douek P;Cormode DP
通讯作者：
Cormode DP
DOI：
10.1016/j.jconrel.2017.02.001
发表时间：
2017-03-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Ashrafi K;Tang Y;Britton H;Domenge O;Blino D;Bushby AJ;Shuturminska K;den Hartog M;Radaelli A;Negussie AH;Mikhail AS;Woods DL;Krishnasamy V;Levy EB;Wood BJ;Willis SL;Dreher MR;Lewis AL
通讯作者：
Lewis AL
影响因子：
9.5
作者：
Hsu JC;Du Y;Sengupta A;Dong YC;Mossburg KJ;Bouché M;Maidment ADA;Weljie AM;Cormode DP
通讯作者：
Cormode DP