Assessment of candidate elements for development of spectral photon-counting CT specific contrast agents.
Assessment of candidate elements for development of spectral photon-counting CT specific contrast agents.
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DOI：
10.1038/s41598-018-30570-y
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发表时间：
2018-08-14
影响因子：
4.6
通讯作者：
Cormode DP
中科院分区：
文献类型：
--
作者：
Kim J;Bar-Ness D;Si-Mohamed S;Coulon P;Blevis I;Douek P;Cormode DP
光谱光子计数计算机断层扫描（SPCCT）是一种快速出现的成像模式，它提供了关于单个X射线光子的能量依赖信息，从而实现了准确的材料分解和多种造影剂生成材料的同时定量。需要开发SPCCT特异性造影剂以克服目前使用的碘化造影剂的问题，例如难以与钙化结构区分，并产生SPCCT的全部前景。在这项研究中，对比生成不同的元素进行了研究，使用原型SPCCT扫描仪的基础上修改的临床CT系统和合适的元素，为新型造影剂的开发SPCCT成像。此外，从钽合成纳米颗粒作为概念光谱光子计数CT剂的证明，并测试其体外细胞毒性和造影剂生成，以深入了解从这些元素开发纳米颗粒造影剂的可行性。我们发现钆、镱和钽在光谱光子计数CT成像中产生高对比度，并且可能是用于这种模式的造影剂开发的合适元素。我们对钽基纳米颗粒的概念验证结果强调了这一结论，因为它们具有光谱光子计数CT的可检测性以及生物相容性。
Spectral photon-counting computed tomography (SPCCT) is a rapidly emerging imaging modality that provides energy-dependent information on individual x-ray photons, leading to accurate material decomposition and simultaneous quantification of multiple contrast generating materials. Development of SPCCT-specific contrast agents is needed to overcome the issues with currently used iodinated contrast agents, such as difficulty in differentiation from calcified structures, and yield SPCCT’s full promise. In this study, the contrast generation of different elements is investigated using a prototype SPCCT scanner based on a modified clinical CT system and suitable elements for novel contrast agent development for SPCCT imaging are identified. Furthermore, nanoparticles were synthesized from tantalum as a proof of concept spectral photon-counting CT agent and tested for their in vitro cytotoxicity and contrast generation to provide insight into the feasibility of nanoparticle contrast agent development from these elements. We found that gadolinium, ytterbium and tantalum generate high contrast in spectral photon-counting CT imaging and may be suitable elements for contrast agent development for this modality. Our proof of concept results with tantalum-based nanoparticles underscore this conclusion due to their detectability with spectral photon-counting CT, as well as their biocompatibility.
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影响因子：
4.6
作者：
Cormode DP;Si-Mohamed S;Bar-Ness D;Sigovan M;Naha PC;Balegamire J;Lavenne F;Coulon P;Roessl E;Bartels M;Rokni M;Blevis I;Boussel L;Douek P
通讯作者：
Douek P
全身研究光子计数检测器CT的光谱性能：派生图像集中的定量精度。
影响因子：
3.5
作者：
Leng S;Zhou W;Yu Z;Halaweish A;Krauss B;Schmidt B;Yu L;Kappler S;McCollough C
通讯作者：
McCollough C
影响因子：
12.4
作者：
Kim JY;Ryu JH;Schellingerhout D;Sun IC;Lee SK;Jeon S;Kim J;Kwon IC;Nahrendorf M;Ahn CH;Kim K;Kim DE
通讯作者：
Kim DE
影响因子：
17.1
作者：
Bonitatibus, Peter J., Jr.;Torres, Andrew S.;Marino, Michael E.
通讯作者：
Marino, Michael E.
影响因子：
--
作者：
Cormode, David P.;Naha, Pratap C.;Fayad, Zahi A.
通讯作者：
Fayad, Zahi A.