The difference in endolymphatic hydrostatic pressure elevation induced by isoproterenol between the ampulla and the cochlea.
The difference in endolymphatic hydrostatic pressure elevation induced by isoproterenol between the ampulla and the cochlea.
复制标题
异丙肾上腺素引起壶腹和耳蜗之间内淋巴静水压升高的差异。
DOI：
10.1016/j.anl.2016.07.018
复制
发表时间：
2017
影响因子：
1.7
通讯作者：
Mori N.
中科院分区：
文献类型：
--
作者：
Inamoto R;Miyashita T;Matsubara A;Hoshikawa H;Mori N.
目的探讨上、下部内淋巴静水压对β-肾上腺素能受体激动剂异丙肾上腺素反应的差异。 结果壶腹部和耳蜗内淋巴液和外淋巴液的静水压大小相似。异丙肾上腺素显着增加壶腹和耳蜗内淋巴和外淋巴的静水压，而壶腹内淋巴电位和耳蜗内电位分别没有变化。异丙肾上腺素引起的壶腹内淋巴静水压最大变化显着 (p< 0.01) 小于耳蜗。在内淋巴囊阻塞的耳朵中，异丙肾上腺素对壶腹内淋巴静水压的作用与耳蜗一样消失。结论异丙肾上腺素以不同的方式升高前庭和耳蜗内淋巴静水压。
ObjectiveThe purpose of the study was to investigate the difference in the responses of endolymphatic hydrostatic pressure to isoproterenol, β-adrenergic receptor agonist, between pars superior and pars inferior.MethodsThe hydrostatic pressure of endolymph and perilymph and endolymphatic potential in the ampulla and the cochlea during the intravenous administration of isoproterenol were recorded using a servo-null system in guinea pigs.ResultsThe hydrostatic pressure of endolymph and perilymph in the ampulla and cochlea was similar in magnitude. Isoproterenol significantly increased hydrostatic pressure of ampullar and cochlear endolymph and perilymph with no change in the ampullar endolymphatic potential and endocochlear potential, respectively. The isoproterenol-induced maximum change of endolymphatic hydrostatic pressure in ampulla was significantly (p< 0.01) smaller than that in the cochlea. In ears with an obstructed endolymphatic sac, the action of isoproterenol on endolymphatic hydrostatic pressure in the ampulla disappeared like that in the cochlea.ConclusionIsoproterenol elevates endolymphatic hydrostatic pressure in different manner between the vestibule and the cochlea.
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