Aging profoundly delays functional recovery from gustatory nerve injury.
Aging profoundly delays functional recovery from gustatory nerve injury.
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DOI：
10.1016/j.neuroscience.2012.02.012
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发表时间：
2012-05-03
期刊：
影响因子：
3.3
通讯作者：
McCluskey, L. P.
中科院分区：
文献类型：
--
作者：
He, L.;Yadgarov, A.;Sharif, S.;McCluskey, L. P.
在成年期，外周味觉系统保持可塑性。切断从舌前部向中枢神经系统发送感觉信息的鼓索（CT）神经，会导致远端纤维和目标味蕾的变性。然而，年轻成年啮齿动物的味觉功能在大约40天后恢复。我们测试了老化是否影响单侧CT神经损伤后神经反应的再现。味蕾再生在去神经后50-65天是最小的，大多数老年动物在功能恢复之前就已经死亡。老龄大鼠的一个子集（n=3/5）在切片后第85天表现出正常的CT反应，表明有效恢复的潜力。衰老的味觉系统对感觉受体的丧失和正常衰老过程中的主要功能变化具有相当的弹性。然而，味觉系统的损伤揭示了老年啮齿动物令人惊讶的脆弱性。味觉系统提供了一个很好的模型来研究周围神经损伤后延迟恢复的机制。随着老年人口的持续增长，加快康复和恢复正常功能的战略将受到关注。
The peripheral taste system remains plastic during adulthood. Sectioning the chorda tympani (CT) nerve, which sends sensory information from the anterior tongue to the CNS, causes degeneration of distal fibers and target taste buds. However, taste function is restored after about 40 days in young adult rodents. We tested whether aging impacts the reappearance of neural responses after unilateral CT nerve injury. Taste bud regeneration was minimal at day 50–65 after denervation, and most aged animals died before functional recovery could be assessed. A subset (n=3/5) of old rats exhibited normal CT responses at day 85 post-sectioning, suggesting the potential for efficient recovery. The aged taste system is fairly resilient to sensory receptor loss and major functional changes in normal aging. However, injury to the taste system reveals a surprising vulnerability in old rodents. The gustatory system provides an excellent model to study mechanisms underlying delayed recovery from peripheral nerve injury. Strategies to accelerate recovery and restore normal function will be of interest as the elderly population continues to grow.
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影响因子：
3.4
作者：
Apel, Peter J.;Ma, Jianjun;Callahan, Michael;Northam, Casey N.;Alton, Timothy B.;Sonntag, William E.;Li, Zhongyu
通讯作者：
Li, Zhongyu
影响因子：
4.2
作者：
Cavallin, MA;McCluskey, LP
通讯作者：
McCluskey, LP
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影响因子：
2.5
作者：
Cavallin, Melissa Ann;McCluskey, Lynnette Phillips
通讯作者：
McCluskey, Lynnette Phillips
影响因子：
2.8
作者：
Apel, Peter J.;Alton, Timothy;Northam, Casey;Ma, Jianjun;Callahan, Michael;Sonntag, William E.;Li, Zhongyu
通讯作者：
Li, Zhongyu
DOI：
10.1152/ajpregu.00219.2009
发表时间：
2009-10-01
影响因子：
2.8
作者：
Guagliardo, Nick A.;West, Katie Nicole;Hill, David L.
通讯作者：
Hill, David L.