Fast, accurate, point-of-care COVID-19 pandemic diagnosis enabled through advanced lab-on-chip optical biosensors: Opportunities and challenges.
Fast, accurate, point-of-care COVID-19 pandemic diagnosis enabled through advanced lab-on-chip optical biosensors: Opportunities and challenges.
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DOI：
10.1063/5.0022211
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发表时间：
2021-09
影响因子：
15
通讯作者：
Chen RT
中科院分区：
文献类型：
--
作者：
Asghari A;Wang C;Yoo KM;Rostamian A;Xu X;Shin JD;Dalir H;Chen RT
2020年初全球严重急性呼吸系统综合症冠状病毒2型（SARS-CoV-2）疫情突然上升，要求采取严厉的行动措施，以进行即时检测并降低传播速度。常见的临床和非临床诊断检测方法在满足快速检测床旁（POC）方法以减缓进一步传播的日益增长的需求方面部分有效。然而，对这种新出现的病毒感染进行准确的风险点诊断至关重要，因为同时需要标准操作程序和SARS-CoV-2的症状管理将成为未来几年的常态。一个敏感的，具有大规模生产能力的成本效益的生物传感器是至关重要的，直到一个普遍的疫苗接种成为可能。光学生物传感器可以提供一个非侵入性的，非常敏感的快速检测平台，灵敏度下降到1067 fg/ml（1 fM）的浓度在几分钟内。这些生物传感器可以大规模（数百万）生产，以检测鼻、唾液、尿液和血清样本中的COVID-19病毒载量，即使感染者已无症状。这里研究的方法是最先进的生物传感光学器件的可用平台，这些器件是由最先进的设计和材料集成而成的。这些方法包括但不限于集成光学器件、等离子体共振和新兴的纳米材料生物传感器。本文研究的芯片实验室平台不仅适用于SARS-CoV-2刺突蛋白检测，也适用于其他传染性病毒体，如流感和中东呼吸综合征（MERS）。
The sudden rise of the worldwide severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in early 2020 has called into drastic action measures to perform instant detection and reduce the rate of spread. Common clinical and nonclinical diagnostic testing methods have been partially effective in satisfying the increasing demand for fast detection point-of-care (POC) methods to slow down further spread. However, accurate point-of-risk diagnosis of this emerging viral infection is paramount as the need for simultaneous standard operating procedures and symptom management of SARS-CoV-2 will be the norm for years to come. A sensitive, cost-effective biosensor with mass production capability is crucial until a universal vaccination becomes available. Optical biosensors can provide a noninvasive, extremely sensitive rapid detection platform with sensitivity down to ∼67 fg/ml (1 fM) concentration in a few minutes. These biosensors can be manufactured on a mass scale (millions) to detect the COVID-19 viral load in nasal, saliva, urine, and serological samples, even if the infected person is asymptotic. Methods investigated here are the most advanced available platforms for biosensing optical devices that have resulted from the integration of state-of-the-art designs and materials. These approaches include, but are not limited to, integrated optical devices, plasmonic resonance, and emerging nanomaterial biosensors. The lab-on-chip platforms examined here are suitable not only for SARS-CoV-2 spike protein detection but also for other contagious virions such as influenza and Middle East respiratory syndrome (MERS).
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DOI：
10.3390/bios6010001
发表时间：
2016-01-06
期刊：
Biosensors
影响因子：
--
作者：
Chalyan T;Guider R;Pasquardini L;Zanetti M;Falke F;Schreuder E;Heideman RG;Pederzolli C;Pavesi L
通讯作者：
Pavesi L
影响因子：
64.8
作者：
Chen, Chi-Fan;Park, Cheol-Hwan;Wang, Feng
通讯作者：
Wang, Feng
影响因子：
12.6
作者：
Chang, Ching-Wen;Xu, Xiaochuan;Chen, Ray T.
通讯作者：
Chen, Ray T.
影响因子：
12.6
作者：
Abbas A;Linman MJ;Cheng Q
通讯作者：
Cheng Q
影响因子：
12.6
作者：
Ahmadivand A;Gerislioglu B;Ramezani Z;Kaushik A;Manickam P;Ghoreishi SA
通讯作者：
Ghoreishi SA