Hepatic nervous system and neurobiology of the liver.
Hepatic nervous system and neurobiology of the liver.
复制标题
DOI：
10.1002/cphy.c120018
复制
发表时间：
2013-04
影响因子：
5.8
通讯作者：
Glaser S
中科院分区：
文献类型：
--
作者：
Jensen KJ;Alpini G;Glaser S
肝脏有一个神经系统，包含传入和传出神经元，参与许多过程。传入臂包括对脂质、葡萄糖和代谢物（进食和饮水后）的感觉，并触发神经系统做出适当的生理变化。传出臂对于代谢调节、纤维化和胆道功能的调节以及许多其他过程的控制是必不可少的。实验模型帮助我们确定：（i）肝脏是如何受自主神经系统支配的;以及（ii）参与这些过程的细胞类型。因此，肝脏作为受神经信号和消融影响的传感器和效应器。了解这些过程对糖尿病和肥胖症等疾病过程具有重要意义，这些疾病过程受食欲和激素信号的影响。
The liver has a nervous system containing both afferent and efferent neurons that are involved in a number of processes. The afferent arm includes the sensation of lipids, glucose, and metabolites (after eating and drinking) and triggers the nervous system to make appropriate physiological changes. The efferent arm is essential for metabolic regulation, modulation of fibrosis and biliary function and the control of a number of other processes. Experimental models have helped us to establish how: (i) the liver is innervated by the autonomic nervous system; and (ii) the cell types that are involved in these processes. Thus, the liver acts as both a sensor and effector that is influenced by neurological signals and ablation. Understanding these processes hold significant implications in disease processes such as diabetes and obesity, which are influenced by appetite and hormonal signals.
登录
查看更多内容
影响因子：
15.9
作者：
Alvaro, D;Alpini, G;Benedetti, A
通讯作者：
Benedetti, A
影响因子：
1.6
作者：
Fukuda, Y;Imoto, M;Hayakawa, T
通讯作者：
Hayakawa, T
DOI：
10.1016/0165-1838(84)90023-7
发表时间：
1984-01-01
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
--
作者：
ADACHI, A
通讯作者：
ADACHI, A
影响因子：
2.9
作者：
Donahey, JCK;van Dijk, G;Seeley, RJ
通讯作者：
Seeley, RJ
影响因子：
3.6
作者：
Carreño, FR;Seelaender, MCL
通讯作者：
Seelaender, MCL