Gut Peptide Signaling in the Controls of Food Intake
Gut Peptide Signaling in the Controls of Food Intake
复制标题
肠道肽信号传导在食物摄入控制中的作用
作者：
T. Moran
During a meal and after a meal, ingested nutrients alter the release of a variety of gut peptides that have the potential to modulate food intake. Such feedback peptide signaling can be conceptualized as having three outcomes: meal termination, inhibitory modulation of intake in subsequent meals, and orexigenic modulation. Cholecystokinin, pancreatic glucagons, and amylin are examples of peptides involved in meal termination. They are released rapidly with the onset of feeding and have short durations of action. Peptide YY(3‐36) and glucagon‐like peptide 1 are peptides for which longer‐term feeding inhibitory actions have been proposed. They are released from the distal intestine and have longer durations of actions. Ghrelin is a gastric peptide that stimulates food intake after its exogenous administration. Plasma ghrelin levels fall with feeding and rise with food deprivation. All of these gut peptides have vagal or dorsal hindbrain mediation. Their potential as targets for the development of anti‐obesity treatments is under study.
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肝门输注胰高血糖素抗体可增加大鼠自发进食量。
DOI：
10.1152/ajpregu.1991.261.1.r162
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
--
作者：
LeSauter,J;Noh,U;Geary,N
通讯作者：
Geary,N
影响因子：
29.4
作者：
I. Taylor
通讯作者：
I. Taylor
背内侧后脑参与胆囊收缩素引起的饱腹感。
DOI：
10.1152/ajpregu.1986.251.5.r971
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
--
作者：
Edwards,GL;Ladenheim,EE;Ritter,RC
通讯作者：
Ritter,RC
影响因子：
7.7
作者：
Cummings, DE;Purnell, JQ;Weigle, DS
通讯作者：
Weigle, DS
影响因子：
158.5
作者：
Cummings, DE;Weigle, DS;Purnell, JQ
通讯作者：
Purnell, JQ