The influence of VDR polymorphisms on the type 2 diabetes susceptibility in Chinese: an interaction with hypertriglyceridemia
The influence of VDR polymorphisms on the type 2 diabetes susceptibility in Chinese: an interaction with hypertriglyceridemia
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VDR多态性对中国人2型糖尿病易感性的影响：与高甘油三酯血症的相互作用
DOI：
10.1007/s00438-021-01784-z
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发表时间：
2021-04
影响因子：
3.1
通讯作者：
Xing Li
中科院分区：
文献类型：
--
作者：
Dongdong Zhang;Cheng Cheng;Yan Wang;Yuan Xue;Yaping Liu;Yiming Liu;Mingming Feng;Ze Xu;Wenjie Li;Xing Li
有证据表明，维生素 D 受体 (VDR) 突变与 2 型糖尿病 (T2D) 风险增加有关。然而，VDR 变异和环境因素对 T2D 易感性之间的相互作用仍不清楚。因此，本研究旨在探讨VDR多态性与血清甘油三酯水平对T2D的联合影响。横断面研究共有 2017 名参与者。 Taqman 探针测定应用于 rs3847987 和 rs739837 基因分型。使用多元逻辑回归和一般线性模型来检查VDR变体和TG之间的相互作用分别对T2D易感性和空腹血糖的影响。结果显示，在调整潜在风险因素后，在主导模型下，rs739837 多态性与 T2D 风险增加显着相关（OR = 1.30，95% CI 1.02–1.66）。同时，rs3847987与高甘油三酯血症之间（协同指数[SI]：2.98，95% CI：1.23-7.23）以及rs739837与高甘油三酯血症之间（SI：2.36，95% CI：1.05-5.31）对T2D易感性存在显着的相加相互作用。此外，在高甘油三酯水平（> 1.90 mmol/L）下，空腹血糖与 rs3847987 之间存在显着的线性相关性，且呈反浓度依赖性。该研究进一步证明rs739837和高甘油三酯水平均与中国人群较高的T2D易感性相关。此外，VDR 变异对 T2D 的有害影响可以通过高甘油三酯血症状态来改变。
Evidence shows that mutations in vitamin D receptor (VDR) have been linked with an increased risk of type 2 diabetes (T2D). However, the interaction effect between VDR variants and environmental factors on the T2D susceptibility remained unclear. Therefore, the current study was conducted to explore the joint effect of VDR polymorphisms and serum triglyceride level on T2D. A total of 2017 participants were included in the cross-sectional study. Taqman probe assays were applied to rs3847987 and rs739837 genotyping. Multiple logistic regression and general linear model were used to examine the effect of interaction between VDR variants and TG on T2D susceptibility and fasting serum glucose, respectively. The results showed that rs739837 polymorphism was significantly associated with an increased risk of T2D under the dominant model (OR = 1.30, 95% CI 1.02–1.66), after adjusting for potential risk factors. Meanwhile, there was a significant additive interaction between rs3847987 and hypertriglyceridemia (synergy index [SI]: 2.98, 95% CI: 1.23–7.23) and between rs739837 and hypertriglyceridemia (SI: 2.36, 95% CI: 1.05–5.31) on T2D susceptibility. Additionally, a significant linear association between fasting glucose and rs3847987 had been found at high triglyceride level (> 1.90 mmol/L) with an inversely concentration-dependent manner. The study provided further evidence that rs739837 and high level of triglyceride were both associated with higher T2D susceptibility in Chinese population. Additionally, the detrimental effect of VDR variants on T2D could be modified by hypertriglyceridemia status.
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DOI：
10.4238/2014.november.14.2
发表时间：
2014-11
期刊：
Genetics and molecular research : GMR
影响因子：
--
作者：
J. Xu;Y. Yang;X. Liu;Y. J. Wang
通讯作者：
J. Xu;Y. Yang;X. Liu;Y. J. Wang
影响因子：
13.6
作者：
Andersson, T;Alfredsson, L;Ahlbom, A
通讯作者：
Ahlbom, A
DOI：
10.1016/j.bbadis.2019.03.007
发表时间：
2019-06-01
影响因子：
6.2
作者：
Jahn, Daniel;Dorbath, Donata;Geier, Andreas
通讯作者：
Geier, Andreas
维生素D受体基因多态性与中国汉族人群2型糖尿病风险显着相关
影响因子：
7.7
作者：
Jia, Jian;Ding, Haixia;Shen, Chong
通讯作者：
Shen, Chong
CD36 基因变异通过中国农村成年人肥胖的相互作用与 2 型糖尿病相关
影响因子：
3.5
作者：
Zhang Dongdong;Zhang Ruiyuan;Liu Yu;Sun Xizhuo;Yin Zhaoxia;Li Honghui;Zhao Yang;Wang Bingyuan;Ren Yongcheng;Cheng Cheng;Liu Xuejiao;Liu Dechen;Liu Feiyan;Chen Xu;Liu Leilei;Zhou Qionggui;Xiong Yihan;Xu Qihuan;Liu Jiali;Hong Shihao;You Ziyang;Hu Dongsheng
通讯作者：
Hu Dongsheng