Cortex-dependent corrections as the tongue reaches for and misses targets.
Cortex-dependent corrections as the tongue reaches for and misses targets.
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DOI：
10.1038/s41586-021-03561-9
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发表时间：
2021-06
期刊：
影响因子：
64.8
通讯作者：
Goldberg JH
中科院分区：
文献类型：
--
作者：
Bollu T;Ito BS;Whitehead SC;Kardon B;Redd J;Liu MH;Goldberg JH
Precise tongue control is necessary for drinking, eating and vocalizing. However, because tongue movements are fast and difficult to resolve, neural control of lingual kinematics remains poorly understood. Here we combine kilohertz-frame-rate imaging and a deep-learning-based neural network to resolve 3D tongue kinematics in mice drinking from a water spout. Successful licks required corrective submovements that—similar to online corrections during primate reaches—occurred after the tongue missed unseen, distant or displaced targets. Photoinhibition of anterolateral motor cortex impaired corrections, which resulted in hypometric licks that missed the spout. Neural activity in anterolateral motor cortex reflected upcoming, ongoing and past corrective submovements, as well as errors in predicted spout contact. Although less than a tenth of a second in duration, a single mouse lick exhibits the hallmarks of online motor control associated with a primate reach, including cortex-dependent corrections after misses.
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DOI：
10.1080/14640748708401802
发表时间：
1987-08-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION A-HUMAN EXPERIMENTAL PSYCHOLOGY
影响因子：
--
作者：
ELLIOTT, D;MADALENA, J
通讯作者：
MADALENA, J
影响因子：
64.8
作者：
Komiyama, Takaki;Sato, Takashi R.;Svoboda, Karel
通讯作者：
Svoboda, Karel
DOI：
10.1111/j.1096-3642.1985.tb01178.x
发表时间：
1985-01-01
影响因子：
2.8
作者：
KIER, WM;SMITH, KK
通讯作者：
SMITH, KK
影响因子：
16.6
作者：
Ames, K. Cora;Ryu, Stephen, I;Shenoy, Krishna, V
通讯作者：
Shenoy, Krishna, V
影响因子：
5.3
作者：
Arce-McShane, Fritzie I.;Hatsopoulos, Nicholas G.;Sessle, Barry J.
通讯作者：
Sessle, Barry J.