Brain Imaging Biomarkers for Chronic Pain.
Brain Imaging Biomarkers for Chronic Pain.
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DOI：
10.3389/fneur.2021.734821
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发表时间：
2021
影响因子：
3.4
通讯作者：
Geha P
中科院分区：
文献类型：
--
作者：
Zhang Z;Gewandter JS;Geha P
慢性疼痛的患病率已达到流行程度。除了给个人带来痛苦外，慢性疼痛还与精神和医学共病相关，尤其是药物滥用，并且每年在医疗费用、工资损失和生产力方面给社会造成了高达数千亿美元的巨大成本。慢性疼痛没有治愈方法，也没有定量的诊断或预后工具。在本文中，我们提供证据表明这种情况即将改变。我们首先总结我们目前对大脑在慢性疼痛发病机制中作用的理解。我们特别关注慢性疼痛产生过程中的学习概念，以及边缘脑回路和多巴胺能信号传导（它们是情感学习和决策的基础）在这一过程中的影响。接下来，我们总结了我们实验室以及其他研究小组在不同慢性疼痛状况下的最新脑成像研究结果的数据，重点关注那些具有显著临床应用转化潜力的结果。在整个综述中都强调了慢性疼痛和脑成像研究中的差距。最后，我们通过讨论使用慢性疼痛的脑生物标志物的成本和收益，并与其他潜在标志物进行比较来得出结论。
The prevalence of chronic pain has reached epidemic levels. In addition to personal suffering chronic pain is associated with psychiatric and medical co-morbidities, notably substance misuse, and a huge a societal cost amounting to hundreds of billions of dollars annually in medical cost, lost wages, and productivity. Chronic pain does not have a cure or quantitative diagnostic or prognostic tools. In this manuscript we provide evidence that this situation is about to change. We first start by summarizing our current understanding of the role of the brain in the pathogenesis of chronic pain. We particularly focus on the concept of learning in the emergence of chronic pain, and the implication of the limbic brain circuitry and dopaminergic signaling, which underly emotional learning and decision making, in this process. Next, we summarize data from our labs and from other groups on the latest brain imaging findings in different chronic pain conditions focusing on results with significant potential for translation into clinical applications. The gaps in the study of chronic pain and brain imaging are highlighted in throughout the overview. Finally, we conclude by discussing the costs and benefits of using brain biomarkers of chronic pain and compare to other potential markers.
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影响因子：
16.2
作者：
Baliki, Marwan N.;Geha, Paul Y.;Fields, Howard L.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
5.3
作者：
Baliki, Marwan N.;Chialvo, Dante R.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
影响因子：
5.7
作者：
Berger SE;Vachon-Presseau É;Abdullah TB;Baria AT;Schnitzer TJ;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
6.8
作者：
Ashar YK;Clark J;Gunning FM;Goldin P;Gross JJ;Wager TD
通讯作者：
Wager TD