Input-specific control of reward and aversion in the ventral tegmental area.
Input-specific control of reward and aversion in the ventral tegmental area.
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腹侧被盖区(VTA)多巴胺神经元在与奖赏和动机相关的适应性和病理性脑功能中发挥着重要作用。然而，目前尚不清楚VTA多巴胺神经元亚群是否参与编码不同动机特征的不同回路，以及VTA的输入是否对这些回路进行差异化调制。在这里，我们表明，由于突触连接的不同，激活来自外侧背侧被盖和外侧缰核的VTA输入分别引起小鼠的奖赏和厌恶。外侧背侧被盖神经元优先突触投射到伏核外侧壳的多巴胺神经元，外侧缰核神经元主要突触投射到前额内侧皮质的多巴胺神经元以及VTA尾部的GABA能神经元。这些结果表明，不同的VTA回路产生奖赏和厌恶，从而为理解适应性和病理性动机行为的回路基础提供了一个新的框架。
Ventral tegmental area (VTA) dopamine neurons play important roles in adaptive and pathological brain functions related to reward and motivation. It is unknown, however, if subpopulations of VTA dopamine neurons participate in distinct circuits that encode different motivational signatures and whether inputs to the VTA differentially modulate such circuits. Here we show that because of differences in synaptic connectivity activation of inputs to the VTA from the laterodorsal tegmentum and the lateral habenula elicit reward and aversion in mice, respectively. Laterodorsal tegmentum neurons preferentially synapse on dopamine neurons projecting to nucleus accumbens lateral shell while lateral habenula neurons synapse primarily on dopamine neurons projecting to medial prefrontal cortex as well as on GABAergic neurons in the VTA tail. These results establish that distinct VTA circuits generate reward and aversion and thereby provide a novel framework for understanding the circuit basis of adaptive and pathological motivated behaviors.
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神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
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