Microglia and modifiable life factors: Potential contributions to cognitive resilience in aging.
Microglia and modifiable life factors: Potential contributions to cognitive resilience in aging.
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DOI：
10.1016/j.bbr.2021.113207
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发表时间：
2021-05-07
影响因子：
2.7
通讯作者：
Parikh V
中科院分区：
文献类型：
--
作者：
Duggan MR;Parikh V
鉴于年龄相关的认知能力下降的患病率越来越高，考虑可能促进个体对此类缺陷的弹性的因素和机制是相关的。越来越多的证据表明，小胶质细胞的卓越作用，先天免疫中枢神经系统内的主要介质。人类和动物研究表明，异常的小胶质细胞功能和神经炎症不仅是老年大脑的特征，而且可能导致与年龄相关的痴呆症和阿尔茨海默病。相反，积累的数据表明，可改变的生活方式因素（MLF），如健康饮食，运动和认知参与，可以通过潜在地抑制衰老大脑中的炎症来可靠地提供认知益处。本文综述了近年来小胶质细胞在维持大脑稳态和认知功能方面的研究进展。此外，我们提出了一个综合的机制模型，假设一个人的弹性认知能力下降提供的MLF可能介导的缓解异常小胶质细胞激活老化，随后抑制神经炎症。
Given the increasing prevalence of age-related cognitive decline, it is relevant to consider the factors and mechanisms that might facilitate an individual’s resiliency to such deficits. Growing evidence suggests a preeminent role of microglia, the prime mediator of innate immunity within the central nervous system. Human and animal investigations suggest aberrant microglial functioning and neuroinflammation are not only characteristic of the aged brain, but also might contribute to age-related dementia and Alzheimer’s Disease. Conversely, accumulating data suggest that modifiable lifestyle factors (MLFs), such as healthy diet, exercise and cognitive engagement, can reliably afford cognitive benefits by potentially suppressing inflammation in the aging brain. The present review highlights recent advances in our understanding of the role for microglia in maintaining brain homeostasis and cognitive functioning in aging. Moreover, we propose an integrated, mechanistic model that postulates an individual’s resiliency to cognitive decline afforded by MLFs might be mediated by the mitigation of aberrant microglia activation in aging, and subsequent suppression of neuroinflammation.
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影响因子：
--
作者：
Bo H;Kang W;Jiang N;Wang X;Zhang Y;Ji LL
通讯作者：
Ji LL
影响因子：
4.7
作者：
Andreasson KI;Bachstetter AD;Colonna M;Ginhoux F;Holmes C;Lamb B;Landreth G;Lee DC;Low D;Lynch MA;Monsonego A;O'Banion MK;Pekny M;Puschmann T;Russek-Blum N;Sandusky LA;Selenica ML;Takata K;Teeling J;Town T;Van Eldik LJ
通讯作者：
Van Eldik LJ
影响因子：
3.7
作者：
Basak, Chandramallika;Boot, Walter R.;Voss, Michelle W.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
DOI：
10.1523/jneurosci.2173-12.2012
发表时间：
2012-10-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barrientos RM;Hein AM;Frank MG;Watkins LR;Maier SF
通讯作者：
Maier SF
影响因子：
120.7
作者：
Ball, K;Berch, DB;Willis, SL
通讯作者：
Willis, SL