Quantitative analyses of high-angular resolution diffusion imaging (HARDI)-derived long association fibers in children with sensorineural hearing loss.
Quantitative analyses of high-angular resolution diffusion imaging (HARDI)-derived long association fibers in children with sensorineural hearing loss.
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DOI：
10.1002/jdn.10071
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Takahashi E
中科院分区：
文献类型：
--
作者：
Shiohama T;Chew B;Levman J;Takahashi E
感觉神经性听力损失（SNHL）是由于内耳或其与大脑的连接功能丧失而导致的最常见的发育性感觉障碍。虽然在敏感的早期发育期成功干预听觉剥夺与听力放大和人工耳蜗植入可以改善口语的结果，SNHL患者可能会遭受几种认知功能障碍，包括执行功能缺陷，视觉认知障碍和异常的视觉优势，即使在成功的干预。为了评估长联合纤维是否参与SNHL参与者的听外认知过程损伤的发病机制，我们定量分析了SNHL参与者的高角分辨率弥散成像（HARDI）纤维束成像衍生纤维。在排除先天性疾病、围产期脑损伤或早产的病例后，我们招募了17名年龄在10岁以下的SNHL参与者。在两个半球的胼胝体通路（CP）和6种类型的皮质-皮质联合纤维（弓状束[AF]，下纵束[ILF]，下额枕束[IFOF]，钩束[UF]，扣带束[CF]和穹窿[Fx]）被识别和可视化。在三名深度SNHL参与者中，ILF和IFOF部分未被检测到。与年龄和性别匹配的神经典型对照组（NC）相比，SNHL组中多种类型的纤维体积减少，长度增加，表观扩散系数（ADC）值升高，而各向异性分数（FA）值无差异。SNHL中长联合纤维的损害可能与SNHL的认知功能障碍有关。
Sensorineural hearing loss (SNHL) is the most common developmental sensory disorder due to a loss of function within the inner ear or its connections to the brain. While successful intervention for auditory deprivation with hearing amplification and cochlear implants during a sensitive early developmental period can improve spoken-language outcomes, SNHL patients can suffer several cognitive dysfunctions including executive function deficits, visual cognitive impairment, and abnormal visual dominance in speaking perception even after successful intervention. To evaluate whether long association fibers are involved in the pathogenesis of impairment on the extra-auditory cognitive process in SNHL participants, we quantitatively analyzed high-angular resolution diffusion imaging (HARDI) tractography-derived fibers in participants with SNHL. After excluding cases with congenital disorders, perinatal brain damage, or premature birth, we enrolled 17 participants with SNHL aged under 10 years old. Callosal pathways (CP) and 6 types of cortico-cortical association fibers (arcuate fasciculus [AF], inferior longitudinal fasciculus [ILF], inferior fronto-occipital fasciculus [IFOF], uncinate fasciculus [UF], cingulum fasciculus [CF], and fornix [Fx]) in both hemispheres were identified and visualized. The ILF and IFOF were partly undetected in three profound SNHL participants. Compared to age- and gender-matched neurotypical controls (NC), decreased volumes, increased lengths, and high apparent diffusion coefficient (ADC) values without difference in fractional anisotropy (FA) values were identified in multiple types of fibers in the SNHL group. The impairment of long association fibers in SNHL may partly be related to the association of cognitive dysfunction with SNHL.
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DOI：
10.1002/cne.24267
发表时间：
2017-10-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Berger C;Kühne D;Scheper V;Kral A
通讯作者：
Kral A
影响因子：
3
作者：
Chang Y;Lee HR;Paik JS;Lee KY;Lee SH
通讯作者：
Lee SH
影响因子：
1.4
作者：
Garel, C;Chantrel, E;Sebag, G
通讯作者：
Sebag, G
影响因子：
4.8
作者：
Jeurissen, Ben;Leemans, Alexander;Sijbers, Jan
通讯作者：
Sijbers, Jan
影响因子：
2.8
作者：
Bergeson, Tonya R.;Houston, Derek M.;Miyamoto, Richard T.
通讯作者：
Miyamoto, Richard T.