The leucine-rich repeat domain in plant innate immunity: a wealth of possibilities.

The leucine-rich repeat domain in plant innate immunity: a wealth of possibilities.
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DOI:
10.1111/j.1462-5822.2008.01260.x
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发表时间:
2009-02
影响因子:
3.4
通讯作者:
Dinesh-Kumar SP
Dinesh-Kumar SP
中科院分区:
生物学2区
文献类型:
--
作者:
Padmanabhan M;Cournoyer P;Dinesh-Kumar SP

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植物和动物的先天免疫系统都使用免疫受体来检测病原体并触发防御反应。尽管有不同的进化起源,大多数动植物免疫受体都有一个富含亮氨酸的重复序列(LRR)结构域。LRR结构域采用了一种细长的构象,最大限度地增加了表面积,并已被证明是调节蛋白质-蛋白质相互作用的理想结构。尽管LRR结构域被认为是病原体识别的平台,但植物天然免疫受体的NB-LRR类利用其LRR结构域发挥许多其他作用。本文讨论了植物LRRS的结构域结构以及该基序所扮演的各种角色。
The innate immune system of both plants and animals uses immune receptors to detect pathogens and trigger defence responses. Despite having distinct evolutionary origin, most plant and animal immune receptors have a leucine-rich repeat (LRR) domain. The LRR domain adopts a slender conformation that maximizes surface area and has been shown to be ideal for mediating protein-protein interactions. Although the LRR domain was expected to be a platform for pathogen recognition, the NB-LRR class of plant innate immune receptors uses its LRR domain to carry out many other roles. This review discusses the domain architecture of plant LRRs and the various roles ascribed to this motif.
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