Vestibulosympathetic reflex during the early follicular and midluteal phases of the menstrual cycle.
Vestibulosympathetic reflex during the early follicular and midluteal phases of the menstrual cycle.
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月经周期早期卵泡和黄体中期的前庭交感神经反射。
DOI：
10.1152/ajpendo.00056.2008
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Carter,JasonR
中科院分区：
文献类型：
--
作者：
Lawrence,JohnathanE;Ray,ChesterA;Carter,JasonR
有证据表明，动脉压力感受性反射和前庭交感神经反射都参与了血压的调节，而且两种自主神经反射都集中在延髓的心血管中枢。先前的一份报告表明，与卵泡早期(EF)相比，月经周期黄体中期(ML)的交感压力感受性反射敏感性增加。在这一发现的基础上，我们假设在月经周期的ML阶段存在增强的前庭交感反射。对10例健康女性月经周期EF和ML期的肌交感神经活动(MSNA)、平均动脉压(MAP)和心率低位旋转(HDR)反应进行了测定。ML期血浆雌二醇(Δ)(72±13)pg/ml、孕酮(Δ)(8±2)ng/ml明显高于EF期(P<0.01)。月经周期对静息MSNA、MAP和心率无明显影响(EF：13±3次/min、80±2 mm Hg、65±2次/min；ML：14±3次/min、81±3 mm Hg、±3次/min)。在EF期，高强度心率使Δ升高(Δ为3±1次/分，P<0.0 2)，但对MAP和心率无明显影响(Δ为1±1次/分)。在ML期，心率(Δ)和平均动脉压(MAP)无明显变化(Δ为0±1次/分钟，Δ为4±1次/分)。EF期和ML期对HDR的MSNA和心率反应无差异，但ML期对HDR的MAP反应增强(P<；0.03)。我们的结果表明，月经周期不影响前庭交感神经反射，但似乎改变了ML阶段对HDR的MAP反应。
Evidence suggests that both the arterial baroreflex and vestibulosympathetic reflex contribute to blood pressure regulation, and both autonomic reflexes integrate centrally in the medulla cardiovascular center. A previous report indicated increased sympathetic baroreflex sensitivity during the midluteal (ML) phase of the menstrual cycle compared with the early follicular (EF) phase. On the basis of this finding, we hypothesize an augmented vestibulosympathetic reflex during the ML phase of the menstrual cycle. Muscle sympathetic nerve activity (MSNA), mean arterial pressure (MAP), and heart rate responses to head-down rotation (HDR) were measured in 10 healthy females during the EF and ML phases of the menstrual cycle. Plasma estradiol (Δ72 ± 13 pg/ml,P< 0.01) and progesterone (Δ8 ± 2 ng/ml,P< 0.01) were significantly greater during the ML phase compared with the EF phase. The menstrual cycle did not alter resting MSNA, MAP, and heart rate (EF: 13 ± 3 bursts/min, 80 ± 2 mmHg, 65 ± 2 beats/min vs. ML: 14 ± 3 bursts/min, 81 ± 3 mmHg, 64 ± 3 beats/min). During the EF phase, HDR increased MSNA (Δ3 ± 1 bursts/min,P< 0.02) but did not change MAP or heart rate (Δ0 ± 1 mmHg and Δ1 ± 1 beats/min). During the ML phase, HDR increased both MSNA and MAP (Δ4 ± 1 bursts/min and Δ3 ± 1 mmHg,P< 0.04) with no change in heart rate (Δ0 ± 1 beats/min). MSNA and heart rate responses to HDR were not different between the EF and ML phases, but MAP responses to HDR were augmented during the ML phase (P< 0.03). Our results demonstrate that the menstrual cycle does not influence the vestibulosympathetic reflex but appears to alter MAP responses to HDR during the ML phase.
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影响因子：
3.3
作者：
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DOI：
10.1210/jcem-54-1-121
发表时间：
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DOI：
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DOI：
10.1152/ajpendo.1984.247.4.e431
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The American journal of physiology
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DOI：
10.1016/0026-0495(84)90207-5
发表时间：
1984
期刊：
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影响因子：
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