Cognitive ability changes and dynamics of cortical thickness development in healthy children and adolescents.
Cognitive ability changes and dynamics of cortical thickness development in healthy children and adolescents.
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DOI：
10.1016/j.neuroimage.2013.09.038
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发表时间：
2014-01-01
期刊：
影响因子：
5.7
通讯作者：
Karama S
中科院分区：
文献类型：
--
作者：
Burgaleta M;Johnson W;Waber DP;Colom R;Karama S
智商(IQ)分数在一生中往往保持稳定。然而，在一些健康的人中，随着时间的推移，智商出现了显著的下降或上升。目前尚不清楚这种变化是反映了真实的功能变化，还是仅仅反映了测量误差。在这里，我们应用基于表面的皮质测量法，研究了NIH正常大脑发育研究中相隔两年评估的具有代表性的儿童和青少年样本(n=188，平均年龄=11.59岁)的顶端皮质表面积和厚度与全量智商(FSIQ)、操作智商(PIQ)和言语智商(VIQ)变化的相关性。没有观察到智商测量的变化与皮质表面积的变化之间的显著关联，而FSIQ、PIQ和VIQ的变化与皮质变薄的速度有关，主要是在左额叶区域。FSIQ有可靠提高的参与者平均皮质厚度没有显著变化，而那些FSIQ没有显著变化的参与者皮质厚度有适度下降。重要的是，FSIQ出现大幅下降的个体，皮质厚度的下降幅度最大，也最显著。结果支持这样一种观点，即在相对较短的发育期内，可能会有影响智商的有意义的认知能力变化，并表明这种变化与皮质厚度发育的动力学有关。
Intelligence quotient (IQ) scores tend to remain stable across the lifespan. Nevertheless, in some healthy individuals, significant decreases or increases in IQ have been observed over time. It is unclear whether such changes reflect true functional change or merely measurement error. Here, we applied surface-based corticometry to investigate vertex-wise cortical surface area and thickness correlates of changes in Full Scale IQ (FSIQ), Peformance IQ (PIQ) and Verbal IQ (VIQ) in a representative sample of children and adolescents (n = 188, mean age = 11.59 years) assessed two years apart as part of the NIH Study of Normal Brain Development. No significant associations between changes in IQ measures and changes in cortical surface area were observed, whereas changes in FSIQ, PIQ, and VIQ were related to rates of cortical thinning, mainly in left frontal areas. Participants who showed reliable gains in FSIQ showed no significant changes in cortical thickness on average, whereas those who exhibited no significant FSIQ change showed moderate declines in cortical thickness. Importantly, individuals who showed large decreases in FSIQ displayed the steepest and most significant reductions in cortical thickness. Results support the view that there can be meaningful cognitive ability changes that impact IQ within relatively short developmental periods and show that such changes are associated with the dynamics of cortical thickness development.
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