Biomarkers of phthalates and inflammation: Findings from a subgroup of Women's Health Initiative participants.
Biomarkers of phthalates and inflammation: Findings from a subgroup of Women's Health Initiative participants.
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DOI：
10.1016/j.ijheh.2021.113743
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发表时间：
2021-05
影响因子：
6
通讯作者：
Reeves KW
中科院分区：
文献类型：
--
作者：
Trim A;Hankinson SE;Liu S;Shadyab AH;Meliker J;Bao W;Luo J;Liu B;Manson JE;Tinker L;Bigelow C;Reeves KW
最近的实验工作表明邻苯二甲酸盐可能会加剧炎症。先前的研究尚未探讨接触邻苯二甲酸盐与绝经后女性炎症状态的关系，这些女性患炎症相关慢性疾病的风险较高。我们的目的是检查 443 名绝经后妇女中尿邻苯二甲酸盐生物标志物浓度与 C 反应蛋白 [CRP] 和白细胞介素 6 [IL-6] 循环水平之间的关系，这些妇女被选入妇女健康倡议 (WHI) 内的一项乳腺癌病例对照研究。 1993 年至 1998 年 WHI 登记时提供的尿液样本中总共检测到了 13 种邻苯二甲酸酯代谢物。我们还测量了这些女性血清或血浆样本中 CRP 和 IL-6 的基线水平。使用多变量线性模型研究每种邻苯二甲酸盐生物标志物与 CRP 和 IL-6 相关的作用，调整潜在的混杂因素并具体评估 BMI 的作用。在调整后的模型中，我们观察到邻苯二甲酸单羧壬酯 (MCNP) 与 CRP（β = 0.092；95% CI 0.026，0.158）和 IL-6（β = 0.108；95% CI 0.013，0.204）呈正相关。然而，在进一步调整体重指数（BMI）后，这些正相关性减弱且不显着。相比之下，我们观察到邻苯二甲酸单乙酯 (MEP) (β = -0.019; 95% CI -0.036, -0.001) 和邻苯二甲酸单苄酯 (MBzP) (b = -0.034; 95% CI -0.058, -0.010) 仅在调整 BMI 后与 CRP 水平呈负相关。检查的其他邻苯二甲酸酯生物标志物与 CRP 或 IL-6 水平均无显着相关性。总体而言，这些结果并未表明邻苯二甲酸盐在促进炎症反应中发挥重要作用。未来的前瞻性研究有必要提高对这些关联的理解，特别是在阐明体重指数的作用方面。
Recent experimental work has shown that phthalates may increase inflammation. Prior research has not examined the role of exposure to phthalates in relation to inflammatory status among postmenopausal women who are at higher risk of developing inflammation-related chronic disorders. We aimed to examine the associations of urinary phthalate biomarker concentrations with circulating levels of c-reactive protein [CRP] and interleukin-6 [IL-6] among 443 postmenopausal women selected into a breast cancer case-control study nested within the Women’s Health Initiative (WHI). A total of 13 phthalate metabolites were measured in urine samples provided at WHI enrollment from 1993–1998. We also measured baseline levels of CRP and IL-6 in these women’s serum or plasma samples. Multivariable linear models were used to investigate the role of each phthalate biomarker in relation to CRP and IL-6, adjusting for potential confounding factors and specifically evaluating the role of BMI. In adjusted models we observed positive associations of monocarboxynonyl phthalate (MCNP) with CRP (β= 0.092; 95% CI 0.026, 0.158) and IL-6 (β = 0.108; 95% CI 0.013, 0.204). These positive associations were attenuated and non-significant, however, after further adjustment for body mass index (BMI). In contrast, we observed inverse associations of monoethyl phthalate (MEP) (β = −0.019; 95% CI −0.036, −0.001) and monobenzyl phthalate (MBzP) (b = −0.034; 95% CI −0.058, −0.010) with CRP levels only after adjustment for BMI. Other phthalate biomarkers examined were not significantly associated with either CRP or IL-6 levels. Overall, these results do not suggest an important role for phthalates in promoting an inflammatory response. Future prospective studies are warranted to improve understanding of these associations, particularly in clarifying the role of BMI.
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作者：
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通讯作者：
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