Systemic Mycobacterium kansasii Infection in Two Related Cats.
Systemic Mycobacterium kansasii Infection in Two Related Cats.
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DOI：
10.3390/pathogens9110959
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发表时间：
2020-11-18
期刊：
影响因子：
--
通讯作者：
Gunn-Moore DA
中科院分区：
文献类型：
--
作者：
Černá P;Mitchell JL;Lodzinska J;Cazzini P;Varjonen K;Gunn-Moore DA
由于难以实现病原学诊断、治疗的挑战和问题以及潜在的人畜共患病风险，分枝杆菌感染是兽医学中的主要问题。堪萨斯分枝杆菌是一种生长缓慢的非结核分枝杆菌，可引起人类和动物的疾病。虽然在人类中的感染已经得到了很好的描述，但它可能被误诊为结核病，但在动物中的报告较少。家猫中仅报告了4例。本病例报告描述了系统性M。Kansasii感染的两只兄弟姐妹只在室内的猫，提出了两年半的间隔与皮肤疾病，发现与溶骨性和肺部病理学。杆菌感染通过聚合酶链反应对一只猫腰骶部软组织肿块的细针抽吸物和另一只猫皮肤病变的组织穿刺活检证实了两只猫中的kansasii;干扰素-γ释放试验推断M. avium-complex和M.在两只猫的结核病复合感染，分别。两名患者在使用利福平、阿奇霉素和普多沙星（在cat 2中加N-乙酰半胱氨酸）进行抗菌治疗后完全康复。这份报告强调了成功的治疗系统性M。Kansasii分枝杆菌病的猫和准确诊断这种感染的挑战。
Mycobacterial infections are a major concern in veterinary medicine because of the difficulty achieving an etiological diagnosis, the challenges and concerns of treatment, and the potential zoonotic risk. Mycobacterium kansasii, a slow-growing non-tuberculous mycobacteria, causes disease in both humans and animals. While infections have been well described in humans, where it may be misdiagnosed as tuberculosis, there are fewer reports in animals. Only four cases have been reported in the domestic cat. This case report describes systemic M. kansasii infection in two sibling indoor-only cats that presented two and half years apart with cutaneous disease that was found to be associated with osteolytic and pulmonary pathology. Infection with M. kansasii was confirmed in both cats by polymerase chain reaction on fine-needle aspirate of a lumbosacral soft tissue mass in one cat and on a tissue punch biopsy of a skin lesion in the other; interferon-gamma release assay inferred M. avium-complex and M. tuberculosis-complex infection in the two cats, respectively. Both patients made a full recovery following antimicrobial therapy with rifampicin, azithromycin, and pradofloxacin (plus N-acetyl cysteine in cat 2). This report highlights successful treatment of systemic M. kansasii mycobacteriosis in the cat and the challenge of accurately diagnosing this infection.
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影响因子：
9.4
作者：
Cowan, LS;Mosher, L;Crawford, JT
通讯作者：
Crawford, JT
影响因子：
2.6
作者：
Garosi, L;McConnell, JF;Schatzberg, SJ
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Schatzberg, SJ
影响因子：
2.2
作者：
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通讯作者：
Dominguez, L
影响因子：
4.6
作者：
Bakula, Zofia;Brzostek, Anna;Jagielski, Tomasz
通讯作者：
Jagielski, Tomasz
影响因子：
1.7
作者：
Baral, RM;Metcalfe, SS;Malik, R
通讯作者：
Malik, R